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Inputs to prefrontal cortex support visual recognition in the aging brain
(Scientific Reports, 2016-08-23)
Predictive coding models of brain function propose that top-down cortical signals promote efficient neural codes by carrying predictions of upcoming sensory events. We hypothesized that older brains would employ these codes ...
The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress
(Nature, 2018-11-08)
There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant ...
The Functional Architecture of the Brain Underlies Strategic Deception in Impression Management
(Frontiers, 2017-11-02)
Impression management, as one of the most essential skills of social function, impacts one’s survival and success in human societies. However, the neural architecture underpinning this social skill remains poorly understood. ...
MRSA USA300 at Alaska native medical center, Anchorage, Alaska, USA, 2000-2006
(Centers for Disease Control and Prevention, 2012-01)
To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during ...
A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
(Nature Publishing Group, 2018-02-12)
Dysregulated autophagy is central to the pathogenesis and therapeutic development of cancer. However, how autophagy is regulated in cancer is not well understood and genes that modulate cancer autophagy are not fully ...
Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles?
(PLoS, 2011-04-13)
<p>Background<br>
Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) ...
Hand and Nasal Carriage of Discordant Staphylococcus aureus Isolates among Urban Jail Detainees
(American Society for Microbiology, 2014-09)
In 928 Dallas County Jail detainees, nasal carriage of Staphylococcus aureus was found in 32.8% (26.5% methicillin-susceptible Staphylococcus aureus [MSSA] and 6.3% methicillin-resistant S. aureus [MRSA]), and hand carriage ...
Visualizing virus particle mobility in liquid at the nanoscale
(The Royal Society of Chemistry, 2015-09-04)
Currently, there remains a critical need to develop real-time imaging resources for life sciences. Here, we demonstrate the use of high resolution in situ imaging to observe biological complexes in liquid at the nanoscale. ...
Explaining racial and ethnic inequalities in postpartum allostatic load: Results from a multisite study of low to middle income women
(Elsevier, 2016-12)
Background: Racial and ethnic inequalities in women's health are widely documented, but not for the postpartum period, and few studies examine whether neighborhood, psychosocial, and biological factors explain these gaps ...
Training Paediatric Therapists to Deliver Constraint- Induced Movement Therapy (CIMT) in Sub-Saharan Africa
(Wiley, 2015-05)
Hospitals and therapists in developing countries often seek to learn how to deliver new forms of evidenced-based practice (EBP), including paediatric constraint-induced movement therapy (CIMT). This study examines a ...