Now showing items 1-10 of 160
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from docking of paired connexons, with one ...
Impact of the controlled release of a connexin 43 peptide on corneal wound closure in an STZ model of type I diabetes.
The alpha-carboxy terminus 1 (αCT1) peptide is a synthetically produced mimetic modified from the DDLEI C-terminus sequence of connexin 43 (Cx43). Previous research using various wound healing models have found promising ...
Stuck in Time: Negative Income Shock Constricts the Temporal Window of Valuation Spanning the Future and the Past
Insufficient resources are associated with negative consequences including decreased valuation of future reinforcers. To determine if these effects result from scarcity, we examined the consequences of acute, abrupt changes ...
Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
(Springer Nature, 2018-11-09)
Brain tumor patients commonly present with epileptic seizures. We show that tumor-associated seizures are the consequence of impaired GABAergic inhibition due to an overall loss of peritumoral fast spiking interneurons ...
RNA sequencing and proteomics approaches reveal novel deficits in the cortex ofMecp2-deficient mice, a model for Rett syndrome.
BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with ...
Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation
(National Academy of Sciences, 2008-07)
The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular ...
STAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanism
(Society for Neuroscience, 2014-07-30)
Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here ...
Molecular mechanisms of experience-dependent plasticity in visual cortex
(Royal Society, 2008)
A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular ...
The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
(Frontiers Media Sa, 2017-12-15)
Inhibitory Control Mediates the Association between Perceived Stress and Secure Relationship Quality
Past research has demonstrated negative associations between exposure to stressors and quality of interpersonal relationships among children and adolescents. Nevertheless, underlying mechanisms of this association remain ...