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Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation
(National Academy of Sciences, 2008-07)
The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular ...
Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice
(Frontiers, 2018-01-31)
Arc is a unique immediate early gene (IEG) whose expression is induced as synapses are modified during learning. Newly-synthesized ArcmRNA is rapidly transported throughout dendrites and localizes near recently activated ...
Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients
(Frontiers, 2011-10-04)
Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To better delineate the role of sFlt-1 in ...
IL-7 signalling represses Bcl-6 and the TFH gene Program
(Nature, 2016-01-08)
The transcriptional repressor Bcl-6 is linked to the development of both CD4⁺ T follicular helper (TFH) and central memory T (TCM) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) ...
Eagle Syndrome: A Rare Case of Atraumatic, Painful Cervical Neck Swelling
(Western Journal of Emergency Medicine, 2020-04-23)
Introduction: Painful neck swelling is a common emergency complaint but can present diagnostic challenges. Eagle syndrome is a rare clinical entity in which a pathologically elongated styloid process or ossified stylohyoid ...
Laparoscopic enteropexy for intussusception at Rouxen-Y anastomosis
(Oxford University Press; JSCR Publishing, 2019-04-27)
Roux-en-Y gastric bypass (RYGB) is the most commonly performed bariatric procedure in the world. Jejunojenual intussusception after RYGB is a rare but potentially serious complication. Timely radiographic recognition and ...
The development of myasthenia gravis in a patient with facioscapulohumeral muscular dystrophy: case report and literature review
(PAGEPress, 2019-06-10)
The co-existence of facioscapulohumeral muscle dystrophy (FSHD) and myasthenia gravis (MG) is very rare and few cases have been described in the literature. To increase the awareness of the health care providers, we present ...
Delayed diagnosed atypical case of Andersen-Tawil syndrome
(PAGEPress, 2019)
Andersen-Tawil syndrome (ATS) is characterized by a triad of periodic paralysis, cardiac arrhythmias and distinctive dysmorphic features. Due to its rarity and high degree of clinical and phenotypic variability, a diagnosis ...
Emerging therapeutic roles for NAD⁺ metabolism in mitochondrial and age‑related disorders
(Springer, 2016-07-27)
Nicotinamide adenine dinucleotide (NAD⁺) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD⁺ in its reduced form (i.e. NADH) serves ...
Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature
(PAGEPress, 2019)
Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six ...