Recent Submissions

  • Associability-modulated loss learning is increased in posttraumatic stress disorder 

    Brown, Vanessa M.; Zhu, Lusha; Wang, John M.; Frueh, B. Christopher; King-Casas, Brooks; Chiu, Pearl H. (eLife Sciences, 2018-01-09)
    Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct ...
  • TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion 

    Lamouille, Samy Y.; Connolly, Erin; Smyth, James W.; Akhurst, Rosemary J.; Derynck, Rik (Company of Biologists, 2012-03-01)
    In cancer progression, carcinoma cells gain invasive behavior through a loss of epithelial characteristics and acquisition of mesenchymal properties, a process that can lead to epithelial–mesenchymal transition (EMT). TGF-b ...
  • Optic Nerve Hypoplasia Is a Pervasive Subcortical Pathology of Visual System in Neonates 

    Liang, Chen; Kerr, Alicia; Qui, Yangfengzhong; Cristofoli, Francesca; Van Esch, Hilde; Fox, Michael A.; Mukherjee, Konark (ARVO, 2017-11)
    PURPOSE. Optic nerve hypoplasia (ONH) is the most common cause of childhood congenital blindness in developed nations, yet the fundamental pathobiology of ONH remains unknown. The objective of this study was to employ a ...
  • Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells 

    Cooley, Ian D.; Read, Kaitlin A.; Oestreich, Kenneth J. (Nature, 2015-10-26)
    During infection, naïve CD₄⁺ T helper cells differentiate into specialized effector subsets based upon environmental signals propagated by the cytokine milieu. Recently, this paradigm has been complicated by the demonstration ...
  • Inputs to prefrontal cortex support visual recognition in the aging brain 

    Gilbert, Jessica R.; Moran, Rosalyn J. (Scientific Reports, 2016-08-23)
    Predictive coding models of brain function propose that top-down cortical signals promote efficient neural codes by carrying predictions of upcoming sensory events. We hypothesized that older brains would employ these codes ...
  • RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome 

    Pacheco, Natasha L; Heaven, Michael R; Holt, Leanne M; Crossman, David K; Boggio, Kristin J; Shaffer, Scott A; Flint, Daniel L; Olsen, Michelle L (2017-10-24)
    Abstract Background Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of ...
  • Valuation in major depression is intact and stable in a non-learning environment 

    Chung, Dongil; Kadlec, Kelly; Aimone, Jason A.; McCurry, Katherine; King-Casas, Brooks; Chiu, Pearl H. (Nature, 2017-03-10)
    The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have shown blunted neural and behavioral responses ...
  • Policy Adjustment in a Dynamic Economic Game 

    Li, Jian; McClure, Samuel M.; King-Casas, Brooks; Montague, P. Read (PLOS, 2006-12)
    Making sequential decisions to harvest rewards is a notoriously difficult problem. One difficulty is that the real world is not stationary and the reward expected from a contemplated action may depend in complex ways on ...
  • Neural computations underlying social risk sensitivity 

    Lauharatanahirun, Nina; Christopoulos, George I.; King-Casas, Brooks (Frontiers, 2012-08-02)
    Under standard models of expected utility, preferences over stochastic events are assumed to be independent of the source of uncertainty. Thus, in decision-making, an agent should exhibit consistent preferences, regardless ...
  • Congruence of BOLD Response across Intertemporal Choice Conditions: Fictive and Real Money Gains and Losses 

    Bickel, Warren K.; Pitcock, Jeffery A.; Yi, Richard; Angtuaco, Edgardo J.C. (Society for Neuroscience, 2009-07-08)
    Intertemporal choice is predicated on the valuation of commodities with respect to delay until their receipt. Subjective value of a future outcome decreases, or is discounted, as a function of that delay (Bickel and Johnson, ...
  • A Competing Neurobehavioral Decision Systems model of SES-related health and behavioral disparities 

    Bickel, W.K.; Moody, L.; Quisenberry, A.J.; Ramey, C.T.; Sheffer, C.E. (Elsevier, 2014-07-06)
    We propose that executive dysfunction is an important component relating to the socio-economic status gradient of select health behaviors. We review and find evidence supporting an SES gradient associated with (1) negative ...
  • Neural signature of fictive learning signals in a sequential investment task 

    Lohrenz, Terry; McCabe, Kevin; Camerer, Colin F.; Montague, P. Read (NAS, 2007-04-13)
    Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal ...
  • Predictability Modulates Human Brain Response to Reward 

    Berns, Gregory S.; McClure, Samuel M.; Pagnoni, Guiseppe; Montague, P. Read (Society for Neuroscience, 2001-04-15)
    Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of ...
  • Dendritic Spikes and Their Influence on Extracellular Calcium Signaling 

    Wiest, Michael C.; Eagleman, David M.; King, Richard D.; Montague, P. Read (American Physiological Society, 2000)
    Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular ...
  • Monetary Favors and Their Influence on Neural Responses and Revealed Preference 

    Harvey, Ann H.; Kirk, Ulrich; Denfield, George H.; Montague, P. Read (Society for Neuroscience, 2010-07-14)
    Favors from a sender to a receiver are known to bias decisions made by the recipient, especially when the decision relates to the sender, a feature of social exchange known as reciprocity. Using an art-viewing paradigm ...
  • When Things Are Better or Worse than Expected: The Medial Frontal Cortex and the Allocation of Processing Resources 

    Potts, Geoffrey F.; Martin, Laura E.; Burton, Philip; Montague, P. Read (MIT, 2006)
    Access to limited-capacity neural systems of cognitive control must be restricted to the most relevant information. How the brain identifies and selects items for preferential processing is not fully understood. Anatomical ...
  • LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition 

    Perrett, Stephen P.; Dudek, Serena M.; Eagleman, David; Montague, P. Read; Friedlander, Michael J. (Society for Neuroscience, 2001-04-01)
    One Hertz stimulation of afferents for 15 min with constant interstimulus intervals (regular stimulation) can induce longterm depression (LTD) of synaptic strength in the neocortex. However, it is unknown whether natural ...
  • Neural responses to sanction threats in two-party economic exchange 

    Li, Jian; Xiao, Erte; Houser, Daniel; Montague, P. Read (NAS, 2009-08-11)
    Sanctions are used ubiquitously to enforce obedience to social norms. However, recent field studies and laboratory experiments have demonstrated that cooperation is sometimes reduced when incentives meant to promote prosocial ...
  • Biosensor Approach to Psychopathology Classification 

    Koshelev, Misha; Lohrenz, Terry; Vannucci, Marina; Montague, P. Read (PLOS, 2010-10-21)
    We used a multi-round, two-party exchange game in which a healthy subject played a subject diagnosed with a DSM-IV (Diagnostic and Statistics Manual-IV) disorder, and applied a Bayesian clustering approach to the behavior ...
  • Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis 

    Helekar, Santosh A.; Shin, Jae C.; Mattson, Brandi J.; Bartley, Krystle; Stosic, Milena; Saldana-King, Toni; Montague, P. Read; Hutton, George J. (Frontiers, 2010-11-22)
    In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. ...

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