Now showing items 1-20 of 107

    • Heat transfer model to characterize the focal cooling necessary to suppress spontaneous epileptiform activity 

      Guerra, Reynaldo G.; Davalos, Rafael V.; Garcia, Paul A.; Rubinsky, Boris; Berger, Mitchel (SPIE, 2005-04-14)
      Epilepsy is characterized by paroxysmal transient disturbances of the electrical activity of the brain. Symptoms are manifested as impairment of motor, sensory, or psychic function with or without loss of consciousness or ...
    • Effects of receptor clustering on ligand dissociation kinetics: Theory and simulations 

      Gopalakrishnan, Mahima; Forsten-Williams, K.; Nugent, M. A.; Tauber, U. C. (CELL PRESS, 2005-12-01)
      Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones ...
    • Canine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteins 

      Dickerson, B. D.; Geist, B. L.; Spillman, W. B.; Robertson, J. L. (Optical Society of America, 2007-01-01)
      A cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, ...
    • Mathematical Modeling of Irreversible Electroporation for Treatment Planning 

      Edd, Jon F.; Davalos, Rafael V. (Sage, 2007-08)
      Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a series of electric pulses that ...
    • Image Reconstruction For Bioluminescence Tomography From Partial Measurement 

      Jiang, M.; Zhou, T.; Cheng, J. T.; Cong, W. X.; Wang, Ge (Optical Society of America, 2007-09-01)
      The bioluminescence tomography is a novel molecular imaging technology for small animal studies. Known reconstruction methods require the completely measured data on the external surface, although only partially measured ...
    • Tumor Ablation with Irreversible Electroporation 

      Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Davalos, Rafael V.; Rubinsky, Boris; Mir, Lluis M. (PLOS, 2007-11-07)
      We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ...
    • SBES News, Summer/Fall 2008 

      Unknown author (Virginia Tech, 2008)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences.
    • Digital Spectral Separation Methods And Systems For Bioluminescence Imaging 

      Wang, Ge; Shen, Haiou; Liu, Y.; Cong, A.; Cong, W. X.; Wang, Y.; Dubey, P. (Optical Society of America, 2008-01-01)
      We propose a digital spectral separation (DSS) system and methods to extract spectral information optimally from a weak multispectral signal such as in the bioluminescent imaging (BLI) studies. This system utilizes our ...
    • Bioluminescence Tomography - Inner-light, Insight from Infrared 

      Wang, Ge (2008-06-12)
      Bioluminescence tomography (BLT) is a molecular imaging modality, which derives a bioluminescent source distribution inside a small animal from external bioluminescent signals. We published the first paper on BLT in 2004 ...
    • Spiral Cone-beam CT - Successes with Spiral Scans 

      Wang, Ge (2008-06-12)
      X-ray computed tomography (CT) is instrumental in medicine, industry and homeland security, which depicts internal structures of an object from its shadows projected in a fan-beam or cone-beam from an x-ray source along a ...
    • Fluorescence Tomography - Monitor Malignancy in Mice 

      Cui, Zheng; Wang, Ge (2008-06-12)
      Dr. Cui's group at Wake Forest has been investigating a newly discovered innate anticancer immunity in a colony of cancer resistant mice, and already demonstrated that the anticancer activity in the mice stems from the ...
    • Fast CT Reconstruction - Practical Performance via Parallelization 

      Wang, Ge (2008-06-12)
      Parallel computing has been used to solve large-scale problems in many fields. While CT is being developed towards high-resolution, volumetric, dynamic and spectral imaging, datasets become increasingly large, and ...
    • Interior Tomography - Depict with Direct Data 

      Wang, Ge (2008-06-14)
      While the conventional wisdom states that the interior problem - to reconstruct a region of interest (ROI) only from projection data through the ROI - does not have a unique solution, in June 2007 we published the first ...
    • Bolus-chasing CT Angiography - Catch the Contrast via Control 

      Wang, Ge (2008-06-16)
      Intravenous injection of contrast media is required to enhance conspicuity of the vasculature, organs and tumors in CT angiography (CTA) for diagnosis of cardiovascular structures, peripheral vessels and solid organs. The ...
    • X-ray Grating-based Imaging - Waves Work Wonderfully 

      Wang, Ge (2008-06-17)
      Current x-ray imaging is of critical for clinical and pre-clinical applications but it is fundamentally restricted by the attenuation mechanism. X-ray grating-based imaging represents outstanding opportunities and major ...
    • Axiomatic Imaging Theory - Formulate with Fairness & Fun 

      Wang, Ge (2008-06-17)
      There are many imaging systems. Their performance characterization is important for all applications. Various definitions are introduced for quantification of image resolution, which is the ability of an imaging system to ...
    • Phase Approximation Model - Approximation Amazingly Accurate 

      Wang, Ge (2008-06-20)
      The radiative transfer equation (RTE) well describes the photon propagation but its high computational cost is prohibitive for tomographic imaging. The diffusion approximation (DA) to RTE is the most popular but it only ...
    • Image Warping - Unravel Unevenness into Uniformity 

      Wang, Ge (2008-06-21)
      Demonstrations of anatomical systems computationally extracted from spiral CT images and then unraveled onto a plane in vivo to ultimately conceive 3D individualized models.
    • SBES News, Fall 2009 

      Unknown author (Virginia Tech, 2009)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: Our New Buildings Come to Life.
    • Tissue engineered devices for ligament repair, replacement and regeneration 

      Freeman, Joseph W. (Academic Journals, 2009-12-29)
      The anterior cruciate ligament (ACL) is one of five ligaments in the knee that are important for stability and kinematics. It is also the most commonly injured ligament of the knee and due to its poor healing potential, ...