Now showing items 1-10 of 28
Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability
Ovarian cancer cells are exposed to physical stress in the peritoneal cavity during both tumor growth and dissemination. Ascites build-up in metastatic ovarian cancer further increases the exposure to fluid shear stress. ...
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury
(NATURE PUBLISHING GROUP, 2015-11-05)
A Three-Dimensional in Vitro Tumor Platform for Modeling Therapeutic Irreversible Electroporation
(CELL PRESS, 2012-06-01)
Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the point of recovery. The ablated region ...
Diffusion-based Microfluidic PCR for "One-pot" Analysis of Cells
(The Royal Society of Chemistry, 2014-05-28)
Genetic analysis starting with cell samples often requires multi-step processing including cell lysis, DNA isolation/purification, and polymerase chain reaction (PCR) based assays. When conducted on a microfluidic platform, ...
Electroporation-based delivery of cell-penetrating peptide conjugates of peptide nucleic acids for antisense inhibition of intracellular bacteria
(The Royal Society of Chemistry, 2014-08-14)
Cell penetrating peptides (CPPs) have been used for a myriad of cellular delivery applications and were recently explored for delivery of antisense agents such as peptide nucleic acids (PNAs) for bacterial inhibition. ...
The Mechanistic Influence of Aligned Nanofiber Networks on Cell Shape, Migration and Blebbing Dynamics of Glioma Cells
(The Royal Society of Chemistry, 2013-06-03)
Investigating the mechanistic influence of the tumor microenvironment on cancer cell migration and membrane blebbing is crucial in the understanding and eventual arrest of cancer metastasis. In this study, we investigate ...
Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma
Purpose: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to ...
Thermal loading in flow-through electroporation microfluidic devices
(The Royal Society of Chemistry, 2013-05-15)
Thermal loading effects in flow-through electroporation microfluidic devices have been systematically investigated by using dye-based ratiometric luminescence thermometry. Fluorescence measurements have revealed the crucial ...
Endothelial cell sensing, restructuring, and invasion in collagen hydrogel structures
(The Royal Society of Chemistry, 2015-09-03)
Experimental tools to model cell-tissue interactions will likely lead to new ways to both understand and treat cancer. While the mechanical properties and regulation of invasion have been recently studied for tumor cells, ...
Detecting intracellular translocation of native proteins quantitatively at the single cell level
(The Royal Society of Chemistry, 2014-04-07)
The intracellular localization and movement (i.e. translocation) of proteins are critically correlated with the functions and activation states of these proteins. Simple and accessible detection methods that can rapidly ...