Now showing items 1-20 of 99

    • Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform 

      Skardal, Aleksander; Murphy, Sean V.; Devarasetty, Mahesh; Mead, Ivy; Kang, Hyun-Wook; Seol, Young-Joon; Zhang, Yu Shrike; Shin, Su-Ryon; Zhao, Liang; Aleman, Julio; Hall, Adam R.; Shupe, Thomas D.; Kleensang, Andre; Dokmeci, Mehmet R.; Lee, Sang Jin; Jackson, John D.; Yoo, James J.; Hartung, Thomas; Khademhosseini, Ali; Soker, Shay; Bishop, Colin E.; Atala, Anthony (Springer Nature, 2017-08-18)
      Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases -before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation ...
    • In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening 

      Mazzocchi, Andrea R.; Rajan, Shiny A. P.; Votanopoulos, Konstantinos I.; Hall, Adam R.; Skardal, Aleksander (Springer Nature, 2018-02-13)
      Variability in patient response to anti-cancer drugs is currently addressed by relating genetic mutations to chemotherapy through precision medicine. However, practical benefits of precision medicine to therapy design are ...
    • Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models 

      Tegge, Allison N.; Rodrigues, Richard R.; Larkin, Adam L.; Vu, Lucas; Murali, T. M.; Rajagopalan, Padmavathy (Springer Nature, 2018-07-27)
      Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ...
    • 3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration 

      Kim, Ji Hyun; Seol, Young-Joon; Ko, In Kap; Kang, Hyun-Wook; Lee, Young Koo; Yoo, James J.; Atala, Anthony; Lee, Sang Jin (Springer Nature, 2018-08-17)
      A bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which mimics the structural and functional characteristics of the native tissue, is needed for reconstructive surgery. Rapid progress ...
    • 12th Annual Graduate Student Research Symposium: School of Biomedical Engineering and Sciences 

      Unknown author (Virginia Tech, 2013-05-16)
      The SBES Graduate Student Research Symposium was developed to provide students and faculty the opportunity to interact and exchange research ideas with colleagues and industry personnel. This program book features a schedule ...
    • 2016 Student Symposium: Department of Biomedical Engineering and Mechanics 

      Unknown author (Virginia Tech, 2016)
      The SBES Graduate Student Research Symposium was developed to provide students and faculty the opportunity to interact and exchange research ideas with colleagues and industry personnel. This program book includes a schedule ...
    • 2015 Student Symposium: Department of Biomedical Engineering and Mechanics 

      Unknown author (Virginia Tech, 2015)
      This program book includes a schedule of events and abstracts from the 14th annual School of Biomedical Engineering & Sciences Graduate Student Research Symposium.
    • Tumor Ablation with Irreversible Electroporation 

      Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Davalos, Rafael V.; Rubinsky, Boris; Mir, Lluis M. (PLOS, 2007-11-07)
      We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ...
    • Folic Acid-Conjugated Cellulose Nanocrystals Show High Folate-Receptor Binding Affinity and Uptake by KB and Breast Cancer Cells 

      Bittleman, Katelyn Rose; Dong, Shuping; Roman, Maren; Lee, Yong Woo (American Chemical Society, 2018-10-24)
      The study evaluates cellulose nanocrystals (CNCs) as nanocarriers for targeted, intracellular delivery of molecular agents. CNCs were labeled with fluorescein-5′-isothiocyanate as an imaging agent and conjugated to folic ...
    • Whole Brain Radiation-Induced Impairments in Learning and Memory Are Time-Sensitive and Reversible by Systemic Hypoxia 

      Warrington, Junie P.; Csiszar, Anna; Mitschelen, Matthew; Lee, Yong Woo; Sonntag, William E. (PLOS, 2012-01-18)
      Whole brain radiation therapy (WBRT) is commonly used for treatment of primary and metastatic brain tumors; however, cognitive impairment occurs in 40–50% of brain tumor survivors. The etiology of the cognitive impairment ...
    • Towards Omni-Tomography-Grand Fusion of Multiple Modalities for Simultaneous Interior Tomography 

      Wang, Ge; Zhang, Jie; Gao, Hao; Weir, Victor; Yu, Hengyong; Cong, Wenxiang; Xu, Xiaochen; Shen, Haiou; Bennett, James; Furth, Mark; Wang, Yue; Vannier, Michael (PLOS, 2012-06-29)
      We recently elevated interior tomography from its origin in computed tomography (CT) to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we ...
    • Load-Relaxation Properties of the Human Trunk in Response to Prolonged Flexion: Measuring and Modeling the Effect of Flexion Angle 

      Toosizadeh, Nima; Nussbaum, Maury A.; Bazrgari, Babak; Madigan, Michael L. (PLOS, 2012-11-05)
      Experimental studies suggest that prolonged trunk flexion reduces passive support of the spine. To understand alterations of the synergy between active and passive tissues following such loadings, several studies have ...
    • Pulsed Ultrasound Differentially Stimulates Somatosensory Circuits in Humans as Indicated by EEG and fMRI 

      Legon, Wynn; Rowlands, Abby; Opitz, Alexander; Sato, Tomokazu F.; Tyler, William J. (PLOS, 2012-12-04)
      Peripheral somatosensory circuits are known to respond to diverse stimulus modalities. The energy modalities capable of eliciting somatosensory responses traditionally belong to mechanical, thermal, electromagnetic, and ...
    • SBES News, Summer/Fall 2008 

      Unknown author (Virginia Tech, 2008)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences.
    • SBES News, Fall 2010 

      Unknown author (Virginia Tech, 2010)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: New Medical School, New Research Institute, New Partnerships.
    • SBES News, Fall 2011 

      Unknown author (Virginia Tech, 2011)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: 17 New Faculty Join SBES.
    • SBES News, Fall 2012 

      Unknown author (Virginia Tech, 2012)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: Doubled our Faculty.
    • SBES News, Fall 2013 

      Unknown author (Virginia Tech, 2013)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: Crusade Against Cancer.
    • SBES News, Fall 2009 

      Unknown author (Virginia Tech, 2009)
      This is the annual newsletter for the School of Biomedical Engineering and Sciences. In this issue: Our New Buildings Come to Life.
    • Dynamic, Nondestructive Imaging of a Bioengineered Vascular Graft Endothelium 

      Whited, Bryce M.; Hofmann, Matthias C.; Lu, Peng; Xu, Yong; Rylander, Christopher G.; Wang, Ge; Sapoznik, Etai; Criswell, Tracy; Lee, Sang Jin; Soker, Shay; Rylander, Marissa Nichole (PLOS, 2013-04-09)
      Bioengineering of vascular grafts holds great potential to address the shortcomings associated with autologous and conventional synthetic vascular grafts used for small diameter grafting procedures. Lumen endothelialization ...