Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 71-90 of 132
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Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor
(Springer Nature, 2018-03-12)Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration, inflammation, and joint lubrication. Both the abundance and ... -
Line-Source Based X-Ray Tomography
(Hindawi, 2009-04-27)Current computed tomography (CT) scanners, including micro-CT scanners, utilize a point x-ray source. As we target higher and higher spatial resolutions, the reduced x-ray focal spot size limits the temporal and contrast ... -
Load-Relaxation Properties of the Human Trunk in Response to Prolonged Flexion: Measuring and Modeling the Effect of Flexion Angle
(PLOS, 2012-11-05)Experimental studies suggest that prolonged trunk flexion reduces passive support of the spine. To understand alterations of the synergy between active and passive tissues following such loadings, several studies have ... -
Mathematical Modeling of Irreversible Electroporation for Treatment Planning
(Sage, 2007-08)Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a series of electric pulses that ... -
Mathematical Study and Numerical Simulation of Multispectral Bioluminescence Tomography
(Hindawi, 2006-12-12)Multispectral bioluminescence tomography (BLT) attracts increasinglymore attention in the area of optical molecular imaging. In this paper, we analyzethe properties of the solutions to the regularized and discretized ... -
Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma
(2017)Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Approximately 9180 primary GBM tumors are diagnosed in the United States each year, in which median survival is up to 16 months. GBM eludes ... -
The Mechanistic Influence of Aligned Nanofiber Networks on Cell Shape, Migration and Blebbing Dynamics of Glioma Cells
(The Royal Society of Chemistry, 2013-06-03)Investigating the mechanistic influence of the tumor microenvironment on cancer cell migration and membrane blebbing is crucial in the understanding and eventual arrest of cancer metastasis. In this study, we investigate ... -
A microchip platform for structural oncology applications.
Recent advances in the development of functional materials offer new tools to dissect human health and disease mechanisms. The use of tunable surfaces is especially appealing as substrates can be tailored to fit applications ... -
Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses
(2015-08-27)Background For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, ... -
Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress
(Nature Publishing Group, 2017-03-06)The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic ... -
A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease
(Springer Nature, 2015-09-23)We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ... -
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
(Springer Nature, 2017-08-18)Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases -before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation ... -
N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro
(PLOS, 2017-07-10)It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor ... -
Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta
(2017-07-07)A number of innovative methods exist to measure cell-matrix adhesive forces, but they have yet to accurately describe and quantify the intricate interplay of a cell and its fibrous extracellular matrix (ECM). In cardiovascular ... -
Neural computations underlying social risk sensitivity
(Frontiers, 2012-08-02)Under standard models of expected utility, preferences over stochastic events are assumed to be independent of the source of uncertainty. Thus, in decision-making, an agent should exhibit consistent preferences, regardless ... -
Non-Invasive Detection of Respiration and Heart Rate with a Vehicle Seat Sensor
(MDPI, 2018-05-08)This study demonstrates the feasibility of using a seat sensor designed for occupant classification from a production passenger vehicle to measure an occupant’s respiration rate (RR) and heart rate (HR) in a laboratory ... -
Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties
(Hindawi, 2011-12-22)Quantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate ... -
A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.
(2012-04)Voltage clamping is an important tool for measuring individual currents from an electrically active cell. However, it is difficult to isolate individual currents without pharmacological or voltage inhibition. Herein, we ... -
A Numerical Investigation of the Electric and Thermal Cell Kill Distributions in Electroporation-Based Therapies in Tissue
(PLOS, 2014-08-12)Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy (ECT) and gene therapy based on ...
