Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 99-118 of 132
-
Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores
(Springer Nature, 2016-07-07)5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many ... -
Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells
(Hindawi, 2012-10-22)Tumor margin detection for patients undergoing breast conservation surgery primarily occurs postoperatively. Previously, we demonstrated that gold nanoshells rapidly enhance contrast of HER2 overexpression in ex vivo tissue ... -
Real-time prediction of patient immune cell modulation during irreversible electroporation therapy
(2019-11-28)Immunotherapies have demonstrated limited efficacy in pancreatic ductal adenocarcinoma (PDAC) patients despite their success in treating other tumor types. This limitation is largely due to the relatively immunosuppressive ... -
SART-Type Image Reconstruction from a Limited Number of Projections with the Sparsity Constraint
(Hindawi, 2010-04-26)Based on the recent mathematical findings on solving the linear inverse problems with sparsity constraints by Daubechiesx et al., here we adapt a simultaneous algebraic reconstruction technique (SART) for image reconstruction ... -
SART-Type Image Reconstruction from Overlapped Projections
(Hindawi, 2010-09-05)To maximize the time-integrated X-ray flux from multiple X-ray sources and shorten the data acquisition process, a promising way is to allow overlapped projections from multiple sources being simultaneously on without ... -
Sex Differences in beta-Adrenergic Responsiveness of Action Potentials and Intracellular Calcium Handling in Isolated Rabbit Hearts
(PLOS, 2014-10-23)Cardioprotection in females, as observed in the setting of heart failure, has been attributed to sex differences in intracellular calcium handling and its modulation by b-adrenergic signaling. However, further studies ... -
Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study
(Springer, 2015-10-01)It has long been held that electrical excitation spreads from cell-to-cell in the heart via low resistance gap junctions (GJ). However, it has also been proposed that myocytes could interact by non-GJ-mediated “ephaptic” ... -
Sphingolipid Metabolites Modulate Dielectric Characteristics of Cells in a Mouse Ovarian Cancer Progression Model
(The Royal Society of Chemistry, 2013-03-27)Currently, conventional cancer treatment regimens often rely upon highly toxic chemotherapeutics or target oncogenes that are variably expressed within the heterogeneous cell population of tumors. These challenges highlight ... -
A Stationary-Sources and Rotating-Detectors Computed Tomography Architecture for Higher Temporal Resolution and Lower Radiation Dose
(IEEE, 2014)In current computed tomography (CT) architecture, both X-ray tubes and X-ray detectors are rotated mechanically around an object to collect a sufficient number of projections. This architecture has been shown to not be ... -
Stochastic optical reconstruction microscopy-based relative localization analysis (STORM-RLA) for quantitative nanoscale assessment of spatial protein organization
(Amer Soc Cell Biology, 2016-11-07)The spatial association between proteins is crucial to understanding how they function in biological systems. Colocalization analysis of fluorescence microscopy images is widely used to assess this. However, colocalization ... -
Structural analysis of BRCA1 reveals modification hotspot
(Amer Assoc Advancement Science, 2017-09-01) -
Successful Treatment of a Large Soft Tissue Sarcoma With Irreversible Electroporation
(American Society of Clinical Oncology, 2011-05-01)Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues that involves placing minimally invasive electrodes within the targeted region. A series of short, intense electric ... -
Targeted cellular ablation based on the morphology of malignant cells
(NATURE PUBLISHING GROUP, 2015-11-24)Treatment of glioblastoma multiforme (GBM) is especially challenging due to a shortage of methods to preferentially target diffuse infiltrative cells, and therapy-resistant glioma stem cell populations. Here we report a ... -
Temperature-Change-Based Thermal Tomography
(Hindawi, 2009-07-22)Thermal properties of biological tissues play a critical role in the study of tumor angiogenesis and the design and monitoring of thermal therapies. To map thermal parameters noninvasively, we propose temperature-change-based ... -
Temporal Changes in the Required Shoe-Floor Friction when Walking following an Induced Slip
(PLOS, 2014-05-02)Biomechanical aspects of slips and falls have been widely studied to facilitate fall prevention strategies. Prior studies have shown changes in gait after an induced slipping event. As such, most researchers only slip ... -
Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation
(MDPI, 2019-11-23)Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based therapies have demonstrated the ... -
Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine
(Frontiers, 2015-10-20)Both beta adrenergic and musoarinio receptor stimulation independently potentiate arrhy-thmogenesis. However, the effect of simultaneous stimulation on arrhy-thmogenesis is not well known. The purpose of this study was to ... -
A theoretical framework of x-ray dark-field tomography
(Siam Publications, 2011)X-ray mammography is currently the most prevalent imaging modality for screening and diagnosis of breast cancers. However, its success is limited by the poor differentiation between healthy and diseased tissues in the ... -
Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system
(2012-01-30)Background Studies published in the 1970s by Mostafa S. Fahim and colleagues showed that a short treatment with ultrasound caused the depletion of germ cells and infertility. The goal of the current study was to determine ... -
Thermal loading in flow-through electroporation microfluidic devices
(The Royal Society of Chemistry, 2013-05-15)Thermal loading effects in flow-through electroporation microfluidic devices have been systematically investigated by using dye-based ratiometric luminescence thermometry. Fluorescence measurements have revealed the crucial ...
