Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 111-130 of 132
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Targeted cellular ablation based on the morphology of malignant cells
(NATURE PUBLISHING GROUP, 2015-11-24)Treatment of glioblastoma multiforme (GBM) is especially challenging due to a shortage of methods to preferentially target diffuse infiltrative cells, and therapy-resistant glioma stem cell populations. Here we report a ... -
Temperature-Change-Based Thermal Tomography
(Hindawi, 2009-07-22)Thermal properties of biological tissues play a critical role in the study of tumor angiogenesis and the design and monitoring of thermal therapies. To map thermal parameters noninvasively, we propose temperature-change-based ... -
Temporal Changes in the Required Shoe-Floor Friction when Walking following an Induced Slip
(PLOS, 2014-05-02)Biomechanical aspects of slips and falls have been widely studied to facilitate fall prevention strategies. Prior studies have shown changes in gait after an induced slipping event. As such, most researchers only slip ... -
Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation
(MDPI, 2019-11-23)Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based therapies have demonstrated the ... -
Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine
(Frontiers, 2015-10-20)Both beta adrenergic and musoarinio receptor stimulation independently potentiate arrhy-thmogenesis. However, the effect of simultaneous stimulation on arrhy-thmogenesis is not well known. The purpose of this study was to ... -
A theoretical framework of x-ray dark-field tomography
(Siam Publications, 2011)X-ray mammography is currently the most prevalent imaging modality for screening and diagnosis of breast cancers. However, its success is limited by the poor differentiation between healthy and diseased tissues in the ... -
Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system
(2012-01-30)Background Studies published in the 1970s by Mostafa S. Fahim and colleagues showed that a short treatment with ultrasound caused the depletion of germ cells and infertility. The goal of the current study was to determine ... -
Thermal loading in flow-through electroporation microfluidic devices
(The Royal Society of Chemistry, 2013-05-15)Thermal loading effects in flow-through electroporation microfluidic devices have been systematically investigated by using dye-based ratiometric luminescence thermometry. Fluorescence measurements have revealed the crucial ... -
A Three-Dimensional in Vitro Tumor Platform for Modeling Therapeutic Irreversible Electroporation
(CELL PRESS, 2012-06-01)Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the point of recovery. The ablated region ... -
Tissue engineered devices for ligament repair, replacement and regeneration
(Academic Journals, 2009-12-29)The anterior cruciate ligament (ACL) is one of five ligaments in the knee that are important for stability and kinematics. It is also the most commonly injured ligament of the knee and due to its poor healing potential, ... -
TNF alpha Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes
(Frontiers, 2017-05-23)Background: Tumor Necrosis Factor alpha (TNF alpha) upregulation during acute inflammatory response has been associated with numerous cardiac effects including modulating Connexin43 and vascular permeability. This may in ... -
Towards Omni-Tomography-Grand Fusion of Multiple Modalities for Simultaneous Interior Tomography
(PLOS, 2012-06-29)We recently elevated interior tomography from its origin in computed tomography (CT) to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we ... -
Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion
(Biomed Central Ltd, 2010-12-10) -
Towards the development of latent heat storage electrodes for electroporation-based therapies
(American Institute of Physics, 2012-08-22)Phase change materials (PCMs) capable of storing a large amount of heat upon transitioning from the solid-to-liquid state have been widely used in the electronics and construction industries for mitigating temperature ... -
Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models
(Springer Nature, 2018-07-27)Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ... -
Treatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repair
(Hindawi, 2014-03-23)Medical care costs can reach an estimated value of $4 billion for spinal cord injuries (SCI) each year in the USA alone. With no viable treatment options available, care remains palliative and aims to minimize lifelong ... -
Tripping Elicits Earlier and Larger Deviations in Linear Head Acceleration Compared to Slipping
(PLOS, 2016-11-01)Slipping and tripping contribute to a large number of falls and fall-related injuries. While the vestibular system is known to contribute to balance and fall prevention, it is unclear whether it contributes to detecting ... -
Tumor Ablation with Irreversible Electroporation
(PLOS, 2007-11-07)We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ... -
Use of Imaging Biomarkers to Assess Perfusion and Glucose Metabolism in the Skeletal Muscle of Dystrophic Mice
(2011-06-04)Background Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the ... -
Varying Collimation for Dark-Field Extraction
(Hindawi, 2010-02-16)Although x-ray imaging is widely used in biomedical applications, biological soft tissues have small density changes, leading to low contrast resolution for attenuation-based x-ray imaging. Over the past years, x-ray ...
