Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 1-20 of 132
-
3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration
(Springer Nature, 2018-08-17)A bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which mimics the structural and functional characteristics of the native tissue, is needed for reconstructive surgery. Rapid progress ... -
Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers
(Springer Nature, 2015-09-08)MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmotic shocks from lysis. Its high conductance and controllable activation makes it a strong candidate to serve as a transducer in stimuli-responsive ... -
Adsorbing/dissolving Lyoprotectant Matrix Technology for Non-cryogenic Storage of Archival Human Sera
(Springer Nature, 2016-04-12)Despite abundant research conducted on cancer biomarker discovery and validation, to date, less than two-dozen biomarkers have been approved by the FDA for clinical use. One main reason is attributed to inadvertent use of ... -
Aligned fibers direct collective cell migration to engineer closing and nonclosing wound gaps
(2017-09-15)Cell emergence onto damaged or organized fibrous extracellular matrix (ECM) is a crucial precursor to collective cell migration in wound closure and cancer metastasis, respectively. However, there is a fundamental gap in ... -
The assembly of integrated rat intestinal-hepatocyte cultures
(2019-11)The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte ... -
Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2
(PLOS, 2015-08-28)Hair-derived keratin biomaterials composed mostly of reduced keratin proteins (kerateines) have demonstrated their utility as carriers of biologics and drugs for tissue engineering. Electrostatic forces between negatively-charged ... -
Biomechanics of hair cell kinocilia: experimental measurement of kinocilium shaft stiffness and base rotational stiffness with Euler-Bernoulli and Timoshenko beam analysis
(Company of Biologists Ltd., 2011-03-01)Vestibular hair cell bundles in the inner ear contain a single kinocilium composed of a 9+2 microtubule structure. Kinocilia play a crucial role in transmitting movement of the overlying mass, otoconial membrane or cupula ... -
Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth
(Nature Publishing Group, 2015-10-13)Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, ... -
Canine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteins
(Optical Society of America, 2007-01-01)A cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, ... -
Characterization of Ablation Thresholds for 3D-Cultured Patient-Derived Glioma Stem Cells in Response to High-Frequency Irreversible Electroporation
(American Association for the Advancement of Science, 2019-04-28)High-frequency irreversible electroporation (H-FIRE) is a technique that uses pulsed electric fields that have been shown to ablate malignant cells. In order to evaluate the clinical potential of H-FIRE to treat glioblastoma ... -
Characterization of multicellular breast tumor spheroids using image data-driven biophysical mathematical modeling
(2020-07-14)Multicellular tumor spheroid (MCTS) systems provide an in vitro cell culture model system which mimics many of the complexities of an in vivo solid tumor and tumor microenvironment, and are often used to study cancer cell ... -
Composting Animal Carcasses Removed from Roads: An Analysis of Pathogen Destruction and Leachate Constituents in Deer Mortality Static Windrow Composting
(Virginia Center for Transportation Innovation and Research, 2012-06-01)More than 48,700 deer-vehicle collisions occurred in Virginia from 2010 through 2011, the fifth highest number in all U.S. states. The Virginia Department of Transportation (VDOT) is responsible for the removal and disposal ... -
Compressed Sensing Inspired Image Reconstruction from Overlapped Projections
(Hindawi, 2010-06-22)The key idea discussed in this paper is to reconstruct an image from overlapped projections so that the data acquisition process can be shortened while the image quality remains essentially uncompromised. To perform image ... -
Computational and experimental study of chemotaxis of an ensemble of bacteria attached to a microbead
(American Physical Society, 2011-12-12)Micro-objects propelled by whole cell actuators, such as flagellated bacteria, are being increasingly studied and considered for a wide variety of applications. In this work we present theoretical and experimental ... -
Cone-Beam Composite-Circling Scan and Exact Image Reconstruction for a Quasi-Short Object
(Hindawi, 2008-02-03)Here we propose a cone-beam composite-circling mode to solve the quasi-short object problem, which is to reconstruct a short portion of a long object from longitudinally truncated cone-beam data involving the short object. ... -
Connexin 43-Based Therapeutics for Dermal Wound Healing
(MDPI, 2018-06-15)The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of interest for modulating the dermal wound healing response. Observational studies found associations between Cx43 at the wound ... -
Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies
(MDPI, 2020-04-30)Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase ... -
Data-driven statistical modeling of the emergent behavior of biohybrid microrobots
(2020-03-01)Multi-agent biohybrid microrobotic systems, owing to their small size and distributed nature, offer powerful solutions to challenges in biomedicine, bioremediation, and biosensing. Synthetic biology enables programmed ... -
Detecting intracellular translocation of native proteins quantitatively at the single cell level
(The Royal Society of Chemistry, 2014-04-07)The intracellular localization and movement (i.e. translocation) of proteins are critically correlated with the functions and activation states of these proteins. Simple and accessible detection methods that can rapidly ... -
Devices and methods for contactless dielectrophoresis for cell or particle manipulation
(United States Patent and Trademark Office, 2018-09-18)Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may ...
