Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 18-37 of 132
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Data-driven statistical modeling of the emergent behavior of biohybrid microrobots
(2020-03-01)Multi-agent biohybrid microrobotic systems, owing to their small size and distributed nature, offer powerful solutions to challenges in biomedicine, bioremediation, and biosensing. Synthetic biology enables programmed ... -
Detecting intracellular translocation of native proteins quantitatively at the single cell level
(The Royal Society of Chemistry, 2014-04-07)The intracellular localization and movement (i.e. translocation) of proteins are critically correlated with the functions and activation states of these proteins. Simple and accessible detection methods that can rapidly ... -
Devices and methods for contactless dielectrophoresis for cell or particle manipulation
(United States Patent and Trademark Office, 2018-09-18)Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may ... -
Diabetes Increases Cryoinjury Size with Associated Effects on Cx43 Gap Junction Function and Phosphorylation in the Mouse Heart.
(2016)Diabetic patients develop larger myocardial infarctions and have an increased risk of death following a heart attack. The poor response to myocardial injury in the diabetic heart is likely related to the many metabolic ... -
Dielectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis
(American Institute of Physics, 2012-06-01)Ovarian cancer is the leading cause of death from gynecological malignancies in women. The primary challenge is the detection of the cancer at an early stage, since this drastically increases the survival rate. In this ... -
Diffusion-based Microfluidic PCR for "One-pot" Analysis of Cells
(The Royal Society of Chemistry, 2014-05-28)Genetic analysis starting with cell samples often requires multi-step processing including cell lysis, DNA isolation/purification, and polymerase chain reaction (PCR) based assays. When conducted on a microfluidic platform, ... -
Digital Eversion of a Hollow Structure: An Application in Virtual Colonography
(Hindawi, 2008-07-22)A new methodology is presented for digital eversion of a hollow structure. The digital eversion is advantageous for better visualization of a larger portion of the inner surface with preservation of geometric relationship ... -
Digital Spectral Separation Methods And Systems For Bioluminescence Imaging
(Optical Society of America, 2008-01-01)We propose a digital spectral separation (DSS) system and methods to extract spectral information optimally from a weak multispectral signal such as in the bioluminescent imaging (BLI) studies. This system utilizes our ... -
Distinguishing between overdrive excited and suppressed ventricular beats in guinea pig ventricular myocardium
(Frontiers, 2015-02-18)Rapid ventricular pacing rates induces two types of beats following pacing cessation: recovery cycle length (RCL) prolongation (overdrive suppression) and RCL shortening (overdrive excitation). The goals of this study were ... -
Dynamic, Nondestructive Imaging of a Bioengineered Vascular Graft Endothelium
(PLOS, 2013-04-09)Bioengineering of vascular grafts holds great potential to address the shortcomings associated with autologous and conventional synthetic vascular grafts used for small diameter grafting procedures. Lumen endothelialization ... -
Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT
(Hindawi, 2011-08-04)The highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth. We hypothesize that localized mechanical compression reduces ... -
Effects of acute ingestion of different fats on oxidative stress and inflammation in overweight and obese adults.
(2011-11-07)Background Studies show that obese individuals have prolonged elevations in postprandial lipemia and an exacerbated inflammatory response to high fat meals, which can increase risk for cardiovascular diseases. As ... -
Effects of receptor clustering on ligand dissociation kinetics: Theory and simulations
(CELL PRESS, 2005-12-01)Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones ... -
Elastography Method for Reconstruction of Nonlinear Breast Tissue Properties
(Hindawi, 2009-07-09)Elastography is developed as a quantitative approach to imaging linear elastic properties of tissues to detect suspicious tumors. In this paper a nonlinear elastography method is introduced for reconstruction of complex ... -
Electrochemotherapy (ECT) and irreversible electroporation (IRE) -advanced techniques for treating deep-seated tumors based on electroporation
(2015-08-27)When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local defects in the cell membrane appear and become permeable to molecules that otherwise cannot pass through it. This phenomenon ... -
Electroporation-based delivery of cell-penetrating peptide conjugates of peptide nucleic acids for antisense inhibition of intracellular bacteria
(The Royal Society of Chemistry, 2014-08-14)Cell penetrating peptides (CPPs) have been used for a myriad of cellular delivery applications and were recently explored for delivery of antisense agents such as peptide nucleic acids (PNAs) for bacterial inhibition. ... -
Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding
(The Royal Society of Chemistry, 2014-08-08)Fluorescent protein biosensors are typically implemented via genetic encoding which makes the examination of scarce cell samples impractical. By directly delivering the protein form of the biosensor into cells using ... -
Endothelial cell sensing, restructuring, and invasion in collagen hydrogel structures
(The Royal Society of Chemistry, 2015-09-03)Experimental tools to model cell-tissue interactions will likely lead to new ways to both understand and treat cancer. While the mechanical properties and regulation of invasion have been recently studied for tumor cells, ... -
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury
(Nature Publishing Group, 2015-11-05) -
Evaluation of Two Approaches for Aligning Data Obtained from a Motion Capture System and an In-Shoe Pressure Measurement System
(MDPI, 2014-09-12)An in-shoe pressure measurement (IPM) system can be used to measure center of pressure (COP) locations, and has fewer restrictions compared to the more conventional approach using a force platform. The insole of an IPM ...
