Now showing items 1-4 of 4

    • In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening 

      Mazzocchi, Andrea R.; Rajan, Shiny A. P.; Votanopoulos, Konstantinos I.; Hall, Adam R.; Skardal, Aleksander (Springer Nature, 2018-02-13)
      Variability in patient response to anti-cancer drugs is currently addressed by relating genetic mutations to chemotherapy through precision medicine. However, practical benefits of precision medicine to therapy design are ...
    • Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor 

      Rivas, Felipe; Zahid, Osama K.; Reesink, Heidi L.; Peal, Bridgette T.; Nixon, Alan J.; DeAngelis, Paul L.; Skardal, Aleksander; Rahbar, Elaheh; Hall, Adam R. (Springer Nature, 2018-03-12)
      Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration, inflammation, and joint lubrication. Both the abundance and ...
    • Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform 

      Skardal, Aleksander; Murphy, Sean V.; Devarasetty, Mahesh; Mead, Ivy; Kang, Hyun-Wook; Seol, Young-Joon; Zhang, Yu Shrike; Shin, Su-Ryon; Zhao, Liang; Aleman, Julio; Hall, Adam R.; Shupe, Thomas D.; Kleensang, Andre; Dokmeci, Mehmet R.; Lee, Sang Jin; Jackson, John D.; Yoo, James J.; Hartung, Thomas; Khademhosseini, Ali; Soker, Shay; Bishop, Colin E.; Atala, Anthony (Springer Nature, 2017-08-18)
      Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases -before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation ...
    • Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores 

      Zahid, Osama K.; Zhao, Boxuan Simen; He, Chuan; Hall, Adam R. (Springer Nature, 2016-07-07)
      5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many ...