Now showing items 1-10 of 71
Louse- and flea-borne rickettsioses: biological and genomic analyses
(EDP SCIENCES, 2009-03)
In contrast to 15 or more validated and/or proposed tick-borne spotted fever group species, only three named medically important rickettsial species are associated with insects. These insect-borne rickettsiae are comprised ...
Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active anti proliferative and tumor cell differentiation agent
(American Society of Parasitology, 2009-02)
We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for ...
HDP - A novel heme detoxification protein from the malaria parasite
(Public Library of Science, 2008-04-25)
When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification ...
The landscape of human proteins interacting with viruses and other pathogens
(Public Library of Science, 2008-02-15)
Infectious diseases result in millions of deaths each year. Mechanisms of infection have been studied in detail for many pathogens. However, many questions are relatively unexplored. What are the properties of human proteins ...
An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
(Public Library of Science, 2009-01-09)
Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-gamma hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA ...
e-Connections, vol. 1, no. 1; Spring 2006
(Virginia Bioinformatics Institute, Virginia Tech, 2006-04-14)
e-Connections, vol. 4, no. 1; Spring 2009
(Virginia Bioinformatics Institute, Virginia Tech, 2009-03-24)
e-Connections, vol. 3, no. 4; Winter 2008
(Virginia Bioinformatics Institute, Virginia Tech, 2009-01-07)
e-Connections, vol. 3, no. 3; Fall 2008
(Virginia Bioinformatics Institute, Virginia Tech, 2008-09-10)
e-Connections, vol. 2, no. 1; Spring 2007
(Virginia Bioinformatics Institute, Virginia Tech, 2007-04-03)