Now showing items 1-10 of 140
Envisioning Our Future: 2011 & 2012 Highlights
(Virginia Bioinformatics Institute, 2012-12-05)
Systematic Reverse Engineering of Network Topologies: A Case Study of Resettable Bistable Cellular Responses
(Public Library of Science, 2014-08-29)
A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse ...
Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization
(Hindawi Publishing Corporation, 2014-10-23)
Transcranial direct current stimulation (tDCS) continues to demonstrate success as a medical intervention for neurodegenerative diseases, psychological conditions, and traumatic brain injury recovery. One aspect of tDCS ...
Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex
(Public Library of Science, 2015-05-08)
Peroxisome-proliferator activated receptor-γ (PPARγ) is a nuclear hormone receptor that forms a heterodimeric complex with retinoid X receptor-α (RXRα) to regulate transcription of genes involved in fatty acid storage and ...
Transcription Factor Amr1 Induces Melanin Biosynthesis and Suppresses Virulence in Alternaria brassicicola.
(PLOS Pathogens, 2012-10-25)
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of ...
The Plant Pathogen Pseudomonas syringae pv. tomato Is Genetically Monomorphic and under Strong Selection to Evade Tomato Immunity
(PLOS Pathogens, 2011-08-25)
Recently, genome sequencing of many isolates of genetically monomorphic bacterial human pathogens has given new insights into pathogen microevolution and phylogeography. Here, we report a genome-based micro-evolutionary ...
Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
(PLoS ONE, 2011-11-16)
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and ...
Genetic Divergence between Freshwater and Marine Morphs of Alewife (Alosa pseudoharengus): A ‘Next-Generation’ Sequencing Analysis
(PLoS ONE, 2012-03-15)
Alewife Alosa pseudoharengus, a small clupeid fish native to Atlantic Ocean, has recently (,150 years ago) invaded the North American Great Lakes and despite challenges of freshwater environment its populations exploded ...
Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate.
(PLoS Negl Troop Dis, 2013-09-12)
Lassa virus (LASV) is the causative agent of Lassa Fever and is responsible for several hundred thousand infections and thousands of deaths annually in West Africa. LASV and the non-pathogenic Mopeia virus (MOPV) are both ...
Modeling the Role of Peroxisome Proliferator-Activated Receptor _ and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile.
(PLoS ONE, 2012-10-11)
Clostridium difficile is an anaerobic bacterium that has re-emerged as a facultative pathogen and can cause nosocomial diarrhea, colitis or even death. Peroxisome proliferator-activated receptor (PPAR) c has been implicated ...