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Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization
(Hindawi Publishing Corporation, 2014-10-23)
Transcranial direct current stimulation (tDCS) continues to demonstrate success as a medical intervention for neurodegenerative diseases, psychological conditions, and traumatic brain injury recovery. One aspect of tDCS ...
Systematic Reverse Engineering of Network Topologies: A Case Study of Resettable Bistable Cellular Responses
(Public Library of Science, 2014-08-29)
A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse ...
PLoS Computational Biology Conference Postcards from PSB 2010
(Public Library of Science, 2010-04-29)
Welcome to PLoS Conference Postcards. Postcards, as the name suggests, are designed to vividly recount to those not at a conference what happened at the event that was scientifically noteworthy and therefore make the reader ...
What Factors Might Have Led to the Emergence of Ebola in West Africa?
(PLOS, 2015-06-04)
An Ebola outbreak of unprecedented scope emerged in West Africa in December 2013 and presently continues unabated in the countries of Guinea, Sierra Leone, and Liberia. Ebola is not new to Africa, and outbreaks have been ...
A Simulation Optimization Approach to Epidemic Forecasting
(PLOS, 2013-06-27)
Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents ...
Using data-driven agent-based models for forecasting emerging infectious diseases
(Elsevier, 2017-02-22)
Producing timely, well-informed and reliable forecasts for an ongoing epidemic of an emerging infectious disease is a huge challenge. Epidemiologists and policy makers have to deal with poor data quality, limited understanding ...
Mitigation of Epidemics in Contact Networks through Optimal Contact Adaptation
(American Institute of Mathematical Sciences, 2013-08)
This paper presents an optimal control problem formulation to minimize the total number of infection cases during the spread of susceptible-infected-recovered SIR epidemics in contact networks. In the new approach, contact ...
The effect of negative feedback loops on the dynamics of Boolean networks
(CELL PRESS, 2008-07)
Feedback loops play an important role in determining the dynamics of biological networks. To study the role of negative feedback loops, this article introduces the notion of distance-to-positive-feedback which, in essence, ...
Potential Role of a Bistable Histidine Kinase Switch in the Asymmetric Division Cycle of Caulobacter crescentus
(Public Library of Science, 2013-09-12)
The free-living aquatic bacterium, Caulobacter crescentus, exhibits two different morphologies during its life cycle. The morphological change from swarmer cell to stalked cell is a result of changes of function of two ...
A Computational Model of Liver Iron Metabolism
(Public Library of Science, 2013-11-07)
Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular ...