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Genistein Induces Pancreatic beta-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice
(Endocrine Society, 2010-07)
Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. However, studies on whether genistein has an effect on pancreatic beta-cell function are very limited. In the present study, we ...
Potential Role of a Bistable Histidine Kinase Switch in the Asymmetric Division Cycle of Caulobacter crescentus
(Public Library of Science, 2013-09-12)
The free-living aquatic bacterium, Caulobacter crescentus, exhibits two different morphologies during its life cycle. The morphological change from swarmer cell to stalked cell is a result of changes of function of two ...
PLoS Computational Biology Conference Postcards from PSB 2010
(Public Library of Science, 2010-04-29)
Welcome to PLoS Conference Postcards. Postcards, as the name suggests, are designed to vividly recount to those not at a conference what happened at the event that was scientifically noteworthy and therefore make the reader ...
Disparities in spread and control of influenza in slums of Delhi: findings from an agent-based modelling study
(BMJ Publishing Group, 2017-11-03)
Objectives: This research studies the role of slums in the spread and control of infectious diseases in the National Capital Territory of India, Delhi, using detailed social contact networks of its residents.
Methods: ...
A Network Biology Approach to Denitrification in Pseudomonas aeruginosa
(2015-02-23)
Pseudomonas aeruginosa is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, P. aeruginosa can perform (complete) denitrification, a respiratory process of ...
An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
(Public Library of Science, 2009-01-09)
Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-gamma hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA ...
A Computational Model of Liver Iron Metabolism
(Public Library of Science, 2013-11-07)
Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular ...
Multi-scale immunoepidemiological modeling of within-host and between-host HIV dynamics: systematic review of mathematical models
(PeerJ, 2017-09-28)
Objective
The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the ...
Modeling the effect of transient populations on epidemics in Washington DC
(Nature Publishing Group, 2013-11)
Large numbers of transients visit big cities, where they come into contact with many people at crowded areas. However, epidemiological studies have not paid much attention to the role of this subpopulation in disease spread. ...
Quantitative Genetic Background of the Host Influences Gut Microbiomes in Chickens
(Nature Publishing Group, 2013-01)
Host genotype and gender are among the factors that influence the composition of gut microbiota. We studied the population structure of gut microbiota in two lines of chickens maintained under the same husbandry and dietary ...