Now showing items 1-10 of 219
Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae
Background Magnaporthe oryzae, the causal agent of blast disease of rice, is the most destructive disease of rice worldwide. The genome of this fungal pathogen has been sequenced and an automated annotation has recently ...
Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection
Immune responses to Helicobacter pylori are orchestrated through complex balances of host-bacterial interactions, including inflammatory and regulatory immune responses across scales that can lead to the development of the ...
Modeling the Mechanisms by Which HIV Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa
Human immunodeficiency virus (HIV)-infected patients are at an increased risk of co-infection with human papilloma virus (HPV), and subsequent malignancies such as oral cancer. To determine the role of HIV-associated immune ...
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
(Academic Press Ltd Elsevier Science Ltd, 2008-05-29)
Prediction of Disease and Phenotype Associations from Genome-Wide Association Studies
Background Genome wide association studies (GWAS) have proven useful as a method for identifying genetic variations associated with diseases. In this study, we analyzed GWAS data for 61 diseases and phenotypes to elucidate ...
Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures
The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs and environmental ...
Plasmids and Rickettsial Evolution: Insight from Rickettsia felis
Background The genome sequence of Rickettsia felis revealed a number of rickettsial genetic anomalies that likely contribute not only to a large genome size relative to other rickettsiae, but also to phenotypic oddities ...