Now showing items 1-10 of 48
GenomeBlast: a web tool for small genome comparison
Background Comparative genomics has become an essential approach for identifying homologous gene candidates and their functions, and for studying genome evolution. There are many tools available for genome comparisons. ...
Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active anti proliferative and tumor cell differentiation agent
(American Society of Parasitology, 2009-02)
We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for ...
MRM screening/biomarker discovery with linear ion trap MS: a library of human cancer-specific peptides
(Biomed Central Ltd, 2009-03-27)
Background The discovery of novel protein biomarkers is essential in the clinical setting to enable early disease diagnosis and increase survivability rates. To facilitate differential expression analysis and biomarker ...
Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR
Mounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases. For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis ...
Tandemly Arrayed Genes in Vertebrate Genomes
Tandemly arrayed genes (TAGs) are duplicated genes that are linked as neighbors on a chromosome, many of which have important physiological and biochemical functions. Here we performed a survey of these genes in 11 available ...
Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus
The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast ...
Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
(Nature Publishing Group, 2009-01-01)
An emerging cyberinfrastructure for biodefense pathogen and pathogen-host data
The NIAID-funded Biodefense Proteomics Resource Center (RC) provides storage, dissemination, visualization and analysis capabilities for the experimental data deposited by seven Proteomics Research Centers (PRCs). The data ...
Performance comparison between k-tuple distance and four model-based distances in phylogenetic tree reconstruction
Phylogenetic tree reconstruction requires construction of a multiple sequence alignment (MSA) from sequences. Computationally, it is difficult to achieve an optimal MSA for many sequences. Moreover, even if an optimal MSA ...
Writing DNA with GenoCAD (TM)
Chemical synthesis of custom DNA made to order calls for software streamlining the design of synthetic DNA sequences. GenoCAD (TM) (www.genocad.org) is a free web-based application to design protein expression vectors, ...