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dc.contributor.authorRaben, Jaime Melton Schmiegen_US
dc.date.accessioned2013-09-10T08:00:14Z
dc.date.available2013-09-10T08:00:14Z
dc.date.issued2013-09-09en_US
dc.identifier.othervt_gsexam:1629en_US
dc.identifier.urihttp://hdl.handle.net/10919/23762
dc.description.abstractThis work investigates flow measurement capabilities within meso- and micro-scaled medically relevant devices using particle image velocimetry (PIV). Medical devices can be particularly challenging to validate due to small length scales and complex geometries, which can reduce measurement accuracy by introducing noise and reducing available signal. Although the sources of such problems are often device specific, the effective outcome is a reduction in the signal-to-noise ratios (SNRs) of PIV images and correlations. This effort utilizes advanced PIV processing and post-processing techniques to establish protocols for achieving high accuracy PIV measurements in challenging flow environments. This investigation takes place within three wide-ranging medically related devices. First, channel flow in a microfluidic device is investigated to evaluate improvements in measurement accuracy gained using phase correlations in comparison to confocal microscopy. This work found substantial improvements in error with respect to the ensemble field for phase correlations while only moderate improvements were observed for confocal imaging with standard processing techniques. Secondly, an evaluation of stenting procedures was executed resulting in the first published PIV and computational fluid dynamics (CFD) joint study on bifurcating stents. This work analyzes steady flow in three bifurcation angles and four different single- and double-stenting procedures, which are clinically used in coronary bifurcations. Finally, a medical device analog was evaluated to develop a comprehensive CFD validation dataset, including a full uncertainty analysis for velocity and wall shear stress as well as estimates for pressure fields and relevant flow statistics including Reynolds stresses and dissipation.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectparticle image velocimetryen_US
dc.subjectmicro PIVen_US
dc.subjectstenten_US
dc.subjectmedical deviceen_US
dc.titleImprovements in fluidic device evaluation using particle image velocimetryen_US
dc.typeDissertationen_US
dc.contributor.departmentBiomedical Engineeringen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiomedical Engineeringen_US
dc.contributor.committeechairVlachos, Pavlos P.en_US
dc.contributor.committeechairStremler, Mark A.en_US
dc.contributor.committeememberDavalos, Rafael V.en_US
dc.contributor.committeememberBehkam, Baharehen_US
dc.contributor.committeememberRylander, M Nicholeen_US


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