Now showing items 1-2 of 2

    • Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif 

      Zhao, Xiaolin; Xiong, Wen; Xiao, Shuyan; Tang, Tuo-Xian; Ellena, Jeffrey F.; Armstrong, Geoffrey S.; Finkielstein, Carla V.; Capelluto, Daniel G. S. (Nature Publishing Group, 2017-02-22)
      Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains. At these sites, TLRs interact with ...
    • Structure of the GAT domain of the endosomal adapter protein Tom1 

      Xiao, Shuyan; Ellena, Jeffrey F.; Armstrong, Geoffrey S.; Capelluto, Daniel G. S. (Elsevier, 2016-02-24)
      Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in ...