Now showing items 1-9 of 9

    • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

      Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (2019-06-12)
      The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
    • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

      Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (Springer Nature, 2019-06-12)
      The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
    • Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis 

      Luo, Yanting; Lu, Xuemei; Xie, Hehuang (Hindawi, 2014-08-27)
      DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside ...
    • EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity 

      Sun, Zhixiong; Xu, Xiguang; He, Jianlin; Murray, Alexander; Sun, Ming-an; Wei, Xiaoran; Wang, Xia; McCoig, Emmarose; Xie, Evan; Jiang, Xi; Li, Liwu; Zhu, Jinsong; Chen, Jianjun; Morozov, Alexei; Pickrell, Alicia M.; Theus, Michelle H.; Xie, Hehuang (2019-08-29)
      Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
    • HBS-Tools for Hairpin Bisulfite Sequencing Data Processing and Analysis 

      Sun, Ming-an; Velmurugan, Karthik Raja; Keimig, David; Xie, Hehuang (Hindawi, 2015-12-20)
      The emerging genome-wide hairpin bisulfite sequencing (hairpin-BS-Seq) technique enables the determination of the methylation pattern for DNA double strands simultaneously. Compared with traditional bisulfite sequencing ...
    • Identifying Transcriptional Regulatory Modules Among Different Chromatin States in Mouse Neural Stem Cells 

      Banerjee, Sharmi; Zhu, Hongxiao; Tang, Man; Feng, Wu-chun; Wu, Xiaowei; Xie, Hehuang (Frontiers, 2019-01-15)
      Gene expression regulation is a complex process involving the interplay between transcription factors and chromatin states. Significant progress has been made toward understanding the impact of chromatin states on gene ...
    • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

      Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
      Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...
    • Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus 

      He, Jianlin; Xu, Xiguang; Monavarfeshani, Aboozar; Banerjee, Sharmi; Fox, Michael A.; Xie, Hehuang (2019-02-14)
      Abstract DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in ...
    • Virtual methylome dissection facilitated by single-cell analyses 

      Yin, Liduo; Luo, Yanting; Xu, Xiguang; Wen, Shiyu; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (2019-11-11)
      Abstract Background Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It ...