Now showing items 1-4 of 4

    • EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity 

      Sun, Zhixiong; Xu, Xiguang; He, Jianlin; Murray, Alexander; Sun, Ming-an; Wei, Xiaoran; Wang, Xia; McCoig, Emmarose; Xie, Evan; Jiang, Xi; Li, Liwu; Zhu, Jinsong; Chen, Jianjun; Morozov, Alexei; Pickrell, Alicia M.; Theus, Michelle H.; Xie, Hehuang (2019-08-29)
      Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
    • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

      Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
      Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...
    • Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus 

      He, Jianlin; Xu, Xiguang; Monavarfeshani, Aboozar; Banerjee, Sharmi; Fox, Michael A.; Xie, Hehuang (2019-02-14)
      Abstract DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in ...
    • Virtual methylome dissection facilitated by single-cell analyses 

      Yin, Liduo; Luo, Yanting; Xu, Xiguang; Wen, Shiyu; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (2019-11-11)
      Abstract Background Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It ...