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Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage ...
The persistence of low-grade inflammatory monocytes contributes to aggravated Atherosclerosis
Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, the molecular mechanisms responsible for the sustainment of ...