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The persistence of low-grade inflammatory monocytes contributes to aggravated Atherosclerosis
Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, the molecular mechanisms responsible for the sustainment of ...
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage ...