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  • The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar 

    DeHart, Tanner G.; Kushelman, Mara R.; Hildreth, Sherry B.; Helm, Richard F.; Jutras, Brandon L. (Springer Nature, 2021-11-24)
    Peptidoglycan—a mesh sac of glycans that are linked by peptides—is the main component of bacterial cell walls. Peptidoglycan provides structural strength, protects cells from osmotic pressure and contributes to shape. All ...
  • Modeling the effects of Aedes aegypti’s larval environment on adult body mass at emergence 

    Walker, Melody; Chandrasegaran, Karthikeyan; Vinauger, Clément; Robert, Michael A.; Childs, Lauren M. (PLoS, 2021-11-22)
    Mosquitoes vector harmful pathogens that infect millions of people every year, and developing approaches to effectively control mosquitoes is a topic of great interest. However, the success of many control measures is ...
  • Dietary fiber, starch, and sugars in bananas at different stages of ripeness in the retail market 

    Phillips, Katherine M.; McGinty, Ryan C.; Couture, Garret; Pehrsson, Pamela R.; McKillop, Kyle; Fukagawa, Naomi K. (2021-07-08)
    The goal of this work was to evaluate changes in dietary fiber measured by the traditional enzymatic-gravimetric method (AOAC 991.43) and the more recently accepted modified enzymatic-gravimetric method (AOAC 2011.25), ...
  • Biogenic formation of amorphous carbon by anaerobic methanotrophs and select methanogens 

    Allen, Kylie D.; Wegener, Gunter; Sublett, D. Matthew, Jr.; Bodnar, Robert J.; Feng, Xu; Wendt, Jenny; White, Robert H. (AAAS, 2021-10-27)
    Elemental carbon exists in different structural forms including graphite, diamond, fullerenes, and amorphous carbon. In nature, these materials are produced through abiotic chemical processes under high temperature and ...
  • Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity 

    Shi, Hao; Munk, Alexander; Nielsen, Thomas S.; Daughtry, Morgan R.; Larsson, Louise; Li, Shize; Hoyer, Kasper F.; Geisler, Hannah W.; Sulek, Karolina; Kjobsted, Rasmus; Fisher, Taylor; Andersen, Marianne M.; Shen, Zhengxing; Hansen, Ulrik K.; England, Eric M.; Cheng, Zhiyong; Hojlund, Kurt; Wojtaszewski, Jorgen FP P.; Yang, Xiaoyong; Hulver, Matthew W.; Helm, Richard F.; Treebak, Jonas T.; Gerrard, David E. (Elsevier, 2018-05-01)
    Objective: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of ...
  • Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function 

    Keceli, Gizem; Majumdar, Ananya; Thorpe, Chevon N.; Jun, Seungho; Tocchetti, Carlo G.; Lee, Dong; Mahaney, James E.; Paolocci, Nazareno; Toscano, John P. (Rockefeller University Press, 2019-06-01)
    Nitroxyl (HNO) positively modulates myocardial function by accelerating Ca2+ reuptake into the sarcoplasmic reticulum (SR). HNO-induced enhancement of myocardial Ca2+ cycling and function is due to the modification of ...
  • Biosynthesis of the nitrogenase active-site cofactor precursor NifB-co in Saccharomyces cerevisiae 

    Buren, Stefan; Pratt, Katelin; Jiang, Xi; Guo, Yisong; Jimenez-Vicente, Emilio; Echavarri-Erasun, Carlos; Dean, Dennis R.; Saaem, Ishtiaq; Gordon, D. Benjamin; Voigt, Christopher A.; Rubio, Luis M. (National Academy of Sciences, 2019-12-10)
    The radical S-adenosylmethionine (SAM) enzyme NifB occupies a central and essential position in nitrogenase biogenesis. NifB catalyzes the formation of an [8Fe-9S-C] cluster, called NifB-co, which constitutes the core of ...
  • An Updated Perspective on Sinorhizobium meliloti Chemotaxis to Alfalfa Flavonoids 

    Compton, K. Karl; Hildreth, Sherry B.; Helm, Richard F.; Scharf, Birgit E. (Frontiers, 2020-10-23)
    The symbiotic interaction between leguminous plants and their cognate rhizobia allows for the fixation of gaseous dinitrogen into bioavailable ammonia. The perception of host-derived flavonoids is a key initial step for ...
  • The dynamic response of the Arabidopsis root metabolome to auxin and ethylene is not predicted by changes in the transcriptome 

    Hildreth, Sherry B.; Foley, Evan E.; Muday, Gloria K.; Helm, Richard F.; Winkel, Brenda S. J. (Nature Research, 2020-01-20)
    While the effects of phytohormones on plant gene expression have been well characterized, comparatively little is known about how hormones influence metabolite profiles. This study examined the effects of elevated auxin ...
  • The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View 

    Xavier, Joao B.; Young, Vincent B.; Skufca, Joseph; Ginty, Fiona; Testerman, Traci; Pearson, Alexander T.; Macklin, Paul; Mitchell, Amir; Shmulevich, Ilya; Xie, Lei; Caporaso, J. Gregory; Crandall, Keith A.; Simone, Nicole L.; Godoy-Vitorino, Filipa; Griffin, Timothy J.; Whiteson, Katrine L.; Gustafson, Heather H.; Slade, Daniel J.; Schmidt, Thomas M.; Walther-Antonio, Marina RS S.; Korem, Tal; Webb-Robertson, Bobbie-Jo M.; Styczynski, Mark P.; Johnson, W. Evan; Jobin, Christian; Ridlon, Jason M.; Koh, Andrew Y.; Yu, Michael; Kelly, Libusha; Wargo, Jennifer A. (Cell Press, 2020-03-01)
    The collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes ...
  • A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis 

    Land, Eric S.; Cridland, Caitlin A.; Craige, Branch; Dye, Anna; Hildreth, Sherry B.; Helm, Rich F.; Gillaspy, Glenda E.; Perera, Imara Y. (MDPI, 2021-09-04)
    Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation ...
  • Comparative Metabolomics of Fruits and Leaves in a Hyperdiverse Lineage Suggests Fruits Are a Key Incubator of Phytochemical Diversification 

    Schneider, Gerald F.; Salazar, Diego; Hildreth, Sherry B.; Helm, Richard F.; Whitehead, Susan R. (Frontiers, 2021-08-30)
    Interactions between plants and leaf herbivores have long been implicated as the major driver of plant secondary metabolite diversity. However, other plant-animal interactions, such as those between fruits and frugivores, ...
  • Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer 

    Udayasuryan, Barath; Nguyen, Tam T. D.; Slade, Daniel J.; Verbridge, Scott S. (Cell Press, 2020-12-18)
    Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be ...
  • Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis 

    Zamyatin, Anton; Avdeyev, Pavel; Liang, Jiangtao; Sharma, Atashi; Chen, Chujia; Lukyanchikova, Varvara; Alexeev, Nikita; Tu, Zhijian; Alekseyev, Max A.; Sharakhov, Igor V. (Oxford University Press, 2021-03-01)
    Background: Anopheles coluzzii and Anopheles arabiensis belong to the Anopheles gambiae complex and are among the major malaria vectors in sub-Saharan Africa. However, chromosome-level reference genome assemblies are still ...
  • The electronic structure of FeV-cofactor in vanadium-dependent nitrogenase 

    Yang, Zhi-Yong; Jimenez-Vicente, Emilio; Kallas, Hayden; Lukoyanov, Dmitriy A.; Yang, Hao; Martin Del Campo, Julia S.; Dean, Dennis R.; Hoffman, Brian M.; Seefeldt, Lance C. (Royal Society of Chemistry, 2021-03-29)
    The electronic structure of the active-site metal cofactor (FeV-cofactor) of resting-state V-dependent nitrogenase has been an open question, with earlier studies indicating that it exhibits a broad S = 3/2 EPR signal ...
  • Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from Acinetobacter baumannii 

    Valentino, Hannah; Korasick, David A.; Bohac, Tabbetha J.; Shapiro, Justin A.; Wencewicz, Timothy A.; Tanner, John J.; Sobrado, Pablo (American Chemical Society, 2021-07-06)
    Acinetobacter baumannii is an opportunistic pathogen with a high mortality rate due to multi-drug-resistant strains. The synthesis and uptake of the iron-chelating siderophores acinetobactin (Acb) and preacinetobactin ...
  • Protein kinases in Toxoplasma gondii 

    Gaji, Rajshekhar Y.; Sharp, Amanda K.; Brown, Anne M. (2021-05)
    Toxoplasma gondii is an obligatory intracellular pathogen that causes life threatening illness in immunodeficient individuals, miscarriage in pregnant woman, and blindness in newborn children. Similar to any other eukaryotic ...
  • Cation competition and recruitment around the c-kit1 G-quadruplex using polarizable simulations 

    Salsbury, Alexa M.; Lemkul, Justin A. (2021-06-01)
    Nucleic acid-ion interactions are fundamentally important to the physical, energetic, and conformational properties of DNA and RNA. These interactions help fold and stabilize highly ordered secondary and tertiary structures, ...
  • Development of a Certification Exam to Assess Undergraduate Students' Proficiency in Biochemistry and Molecular Biology Core Concepts 

    Zeidan, Quira; Loertscher, Jennifer; Wolfson, Adele J.; Tansey, John T.; Offerdahl, Erika G.; Kennelly, Peter J.; Dries, Daniel R.; Moore, Victoria Del Gaizo; Dean, Diane M.; Carastro, L. Michael; Villafane, Sachel M.; Tyler, Ludmila (2021-06-01)
    With support from the American Society for Biochemistry and Molecular Biology (ASBMB), a community of biochemistry and molecular biology (BMB) scientist-educators has developed and administered an assessment instrument ...
  • A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation 

    Kang, Lin; He, Guijuan; Sharp, Amanda K.; Wang, Xiaofeng; Brown, Anne M.; Michalak, Pawel; Weger-Lucarelli, James (Virginia Tech, 2021-03-05)
    While SARS-CoV-2 likely has animal origins, the viral genetic changes necessary to adapt this animal-derived ancestral virus to humans are largely unknown, mostly due to low levels of sequence polymorphism and the notorious ...

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