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  • Natural and Engineered Sex Ratio Distortion in Insects 

    Compton, Austin; Tu, Zhijian (Frontiers, 2022-06-15)
    Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and ...
  • Warm Blood Meal Increases Digestion Rate and Milk Protein Production to Maximize Reproductive Output for the Tsetse Fly, Glossina morsitans 

    Benoit, Joshua B.; Lahondère, Chloé; Attardo, Geoffrey M.; Michalkova, Veronika; Oyen, Kennan; Xiao, Yanyu; Aksoy, Serap (MDPI, 2022-10-31)
    The ingestion of blood represents a significant burden that immediately increases water, oxidative, and thermal stress, but provides a significant nutrient source to generate resources necessary for the development of ...
  • Ion-Dependent Conformational Plasticity of Telomeric G-Hairpins and G-Quadruplexes 

    Salsbury, Alexa M.; Michel, Haley M.; Lemkul, Justin A. (American Chemical Society, 2022-07-12)
    Telomeric DNA is guanine-rich and can adopt structures such as G-quadruplexes (GQs) and G-hairpins. Telomeric GQs influence genome stability and telomerase activity, making understanding of enzyme-GQ interactions and ...
  • Elucidation of structure-function relationships in Methanocaldococcus jannaschii RNase P, a multi-subunit catalytic ribonucleoprotein 

    Phan, Hong-Duc; Norris, Andrew S.; Du, Chen; Stachowski, Kye; Khairunisa, Bela H.; Sidharthan, Vaishnavi; Mukhopadhyay, Biswarup; Foster, Mark P.; Wysocki, Vicki H.; Gopalan, Venkat (Oxford University Press, 2022-08-12)
    RNase P is a ribonucleoprotein (RNP) that catalyzes removal of the 5 ' leader from precursor tRNAs in all domains of life. A recent cryo-EM study of Methanocaldococcus jannaschii (Mja) RNase P produced a model at 4.6-angstrom ...
  • First Polycipivirus and Unmapped RNA Virus Diversity in the Yellow Crazy Ant, Anoplolepis gracilipes 

    Lee, Chih-Chi; Hsu, Hung-Wei; Lin, Chun-Yi; Gustafson, Nicolas; Matsuura, Kenji; Lee, Chow-Yang; Yang, Chin-Cheng Scotty (MDPI, 2022-09-30)
    The yellow crazy ant, Anoplolepis gracilipes is a widespread invasive ant that poses significant threats to local biodiversity. Yet, compared to other global invasive ant species such as the red imported fire ant ...
  • Nutritional Evaluation of Black Soldier Fly Frass as an Ingredient in Florida Pompano (Trachinotus carolinus L.) Diets 

    Banavar, Amiti; Amirkolaei, Samad Keramat; Duscher, Lexi; Khairunisa, Bela Haifa; Mukhopadhyay, Biswarup; Schwarz, Michael; Urick, Steve; Ovissipour, Reza (MDPI, 2022-09-14)
    The aquaculture industry is in need of sustainable fish feed to reduce the use of expensive and environmentally invasive wild-caught fish currently fed to many carnivorous species. The black soldier fly (BSF) has become a ...
  • A conformational role for NifW in the maturation of molybdenum nitrogenase P-cluster 

    Van Stappen, Casey; Jimenez-Vicente, Emilio; Perez-Gonzalez, Ana; Yang, Zhi-Yong; Seefeldt, Lance C.; DeBeer, Serena; Dean, Dennis R.; Decamps, Laure (Royal Society of Chemistry, 2022-03-24)
    Reduction of dinitrogen by molybdenum nitrogenase relies on complex metalloclusters: the [8Fe:7S] P-cluster and the [7Fe:9S:Mo:C:homocitrate] FeMo-cofactor. Although both clusters bear topological similarities and require ...
  • AnfO controls fidelity of nitrogenase FeFe protein maturation by preventing misincorporation of FeV-cofactor 

    Perez-Gonzalez, Ana; Jimenez-Vicente, Emilio; Salinero-Lanzarote, Alvaro; Harris, Derek F.; Seefeldt, Lance C.; Dean, Dennis R. (Wiley, 2022-05)
    Azotobacter vinelandii produces three genetically distinct, but structurally and mechanistically similar nitrogenase isozymes designated as Mo-dependent, V-dependent, or Fe-only based on the heterometal contained within ...
  • The gut microbial metabolite formate exacerbates colorectal cancer progression 

    Ternes, Dominik; Tsenkova, Mina; Pozdeev, Vitaly Igorevich; Meyers, Marianne; Koncina, Eric; Atatri, Sura; Schmitz, Martine; Karta, Jessica; Schmoetten, Maryse; Heinken, Almut; Rodriguez, Fabien; Delbrouck, Catherine; Gaigneaux, Anthoula; Ginolhac, Aurelien; Tam Thuy Dan Nguyen; Grandmougin, Lea; Frachet-Bour, Audrey; Martin-Gallausiaux, Camille; Pacheco, Maria; Neuberger-Castillo, Lorie; Miranda, Paulo; Zuegel, Nikolaus; Ferrand, Jean-Yves; Gantenbein, Manon; Sauter, Thomas; Slade, Daniel Joseph; Thiele, Ines; Meiser, Johannes; Haan, Serge; Wilmes, Paul; Letellier, Elisabeth (Nature Portfolio, 2022-04)
    Different gut bacteria have been shown to promote colorectal cancer (CRC) progression. The authors identify formate as an oncometabolite derived from Fusobacterium nucleatum, which promotes CRC formation by increasing ...
  • Overview of Diverse Methyl/Alkyl-Coenzyme M Reductases and Considerations for Their Potential Heterologous Expression 

    Gendron, Aleksei; Allen, Kylie D. (Frontiers, 2022-04-25)
    Methyl-coenzyme M reductase (MCR) is an archaeal enzyme that catalyzes the final step of methanogenesis and the first step in the anaerobic oxidation of methane, the energy metabolisms of methanogens and anaerobic methanotrophs ...
  • Anopheles mosquitoes reveal new principles of 3D genome organization in insects 

    Lukyanchikova, Varvara; Nuriddinov, Miroslav; Belokopytova, Polina; Taskina, Alena; Liang, Jiangtao; Reijnders, Maarten J. M. F.; Ruzzante, Livio; Feron, Romain; Waterhouse, Robert M.; Wu, Yang; Mao, Chunhong; Tu, Zhijian Jake; Sharakhov, Igor V.; Fishman, Veniamin (Nature Portfolio, 2022-04-12)
    Chromosomes are hierarchically folded within cell nuclei into territories, domains and subdomains, but the functional importance and evolutionary dynamics of these hierarchies are poorly defined. Here, we comprehensively ...
  • Pathogen Spillover to an Invasive Tick Species: First Detection of Bourbon Virus in Haemaphysalis longicornis in the United States 

    Cumbie, Alexandra N.; Trimble, Rebecca N.; Eastwood, Gillian (MDPI, 2022-04-10)
    Haemaphysalis longicornis (Neumann, 1901) (Acari: Ixodidae), the Asian longhorned tick, is an invasive tick species present in the USA since at least 2017 and has been detected in one-third of Virginia counties. ...
  • Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation 

    Galaski, Johanna; Shhadeh, Amjad; Umana, Ariana; Yoo, Christopher C.; Arpinati, Ludovica; Isaacson, Batya; Berhani, Orit; Singer, Bernhard B.; Slade, Daniel J.; Bachrach, Gilad; Mandelboim, Ofer (2021-07-15)
    F. nucleatum is an anaerobic bacterium that is associated with several tumor entities and promotes tumorigenesis. Recent evidence suggests that F. nucleatum binds the inhibitory receptor carcinoembryonic antigen cell ...
  • CEACAM1 Activation by CbpF-Expressing E. coli 

    Shhadeh, Amjad; Galaski, Johanna; Alon-Maimon, Tamar; Fahoum, Jamal; Wiener, Reuven; Slade, Daniel J.; Mandelboim, Ofer; Bachrach, Gilad (2021-07-29)
    Recent studies on the oral, anaerobic, gram-negative bacterium Fusobacterium nucleatum revealed its presence and involvement in colorectal, esophageal and breast cancer. We previously demonstrated that F. nucleatum binds ...
  • Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation 

    Martin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. (2021-08)
    Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but ...
  • Integration of experimental data and use of automated fitting methods in developing protein force fields 

    Polêto, Marcelo D.; Lemkul, Justin A. (Springer Nature, 2022-03-18)
    The development of accurate protein force fields has been the cornerstone of molecular simulations for the past 50 years. During this period, many lessons have been learned regarding the use of experimental target data and ...
  • Engel Hall News, Fall 2021 

    Unknown author (Virginia Tech, 2021)
    This annual newsletter highlights events, new faculty, and student research in the Department of Biochemistry at Virginia Tech.
  • Engel Hall News, December 2020 

    Unknown author (Virginia Tech, 2020-12)
    This newsletter highlights events, new faculty, and student research in the Department of Biochemistry at Virginia Tech.
  • Species-Specificity in Thermopreference and CO2-Gated Heat-Seeking in Culex Mosquitoes 

    Reinhold, Joanna M.; Chandrasegaran, Karthikeyan; Oker, Helen; Crespo, José E.; Vinauger, Clément; Lahondère, Chloé (MDPI, 2022-01-14)
    Combining thermopreference (Tp) and CO2-gated heat-seeking assays, we studied the thermal preferendum and response to thermal cues in three Culex mosquito species exhibiting ...
  • Sex-Specific Linear Polyubiquitination Is a Critical Regulator of Contextual Fear Memory Formation 

    Musaus, Madeline; Farrell, Kayla; Navabpour, Shaghayegh; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. (Frontiers, 2021-07-09)
    Strong evidence supports that protein ubiquitination is a critical regulator of fear memory formation. However, as this work has focused on protein degradation, it is currently unknown whether polyubiquitin modifications ...

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