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  • Comparison of two DNA extraction methods from larvae, pupae, and adults of Aedes aegypti 

    de la Cruz-Ramos, Josue M.; Hernandez-Triana, Luis M.; Garcia-De la Pena, Cristina; Gonzalez-Alvarez, Vicente H.; Weger-Lucarelli, James; Karmy Siller-Rodriguez, Quetzaly; Sanchez Ramos, Francisco J.; Rodriguez, Americo D.; Ortega-Morales, Aldo, I (2019-10)
    Mosquitoes are the most important arthropods from the point of view of public health, due to the fact that they can transmit a large number of pathogens which can cause diseases to humans and animals. Aedes aegypti (L.) ...
  • NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function 

    Nagai-Singer, Margaret A.; Morrison, Holly A.; Allen, Irving C. (2019-10-11)
    Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization ...
  • Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus 

    Ren, Jingjing; Catalina, Michelle D.; Eden, Kristin; Liao, Xiaofeng; Read, Kaitlin A.; Luo, Xin; McMillan, Ryan P.; Hulver, Matthew W.; Jarpe, Matthew; Bachali, Prathyusha; Grammer, Amrie C.; Lipsky, Peter E.; Reilly, Christopher M. (2019-10-25)
    Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are ...
  • Host nutritional status affects alphavirus virulence, transmission, and evolution 

    Weger-Lucarelli, James; Carrau, Lucia; Levi, Laura I.; Rezelj, Veronica; Vallet, Thomas; Blanc, Herve; Boussier, Jeremy; Megrian, Daniela; Coutermarsh-Ott, Sheryl; LeRoith, Tanya; Vignuzzi, Marco (2019-11)
    Malnourishment, specifically overweight/obesity and undernourishment, affects more than 2.5 billion people worldwide, with the number affected ever-increasing. Concurrently, emerging viral diseases, particularly those that ...
  • Real-time prediction of patient immune cell modulation during irreversible electroporation therapy 

    Beitel-White, N.; Martin, R. C. G.; Li, Y.; Brock, R. M.; Allen, Irving C.; Davalos, R. V. (2019-11-28)
    Immunotherapies have demonstrated limited efficacy in pancreatic ductal adenocarcinoma (PDAC) patients despite their success in treating other tumor types. This limitation is largely due to the relatively immunosuppressive ...
  • Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid 

    Jo, Ami; Ringel-Scaia, Veronica M.; McDaniel, Dylan K.; Thomas, Cassidy A.; Zhang, Rui; Riffle, Judy S.; Allen, Irving C.; Davis, Richey M. (2020-01-20)
    Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in ...
  • Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function 

    McDaniel, Dylan K.; Ringel-Scaia, Veronica M.; Morrison, Holly A.; Coutermarsh-Ott, Sheryl; Council-Troche, McAlister; Angle, Jonathan W.; Perry, Justin B.; Davis, Grace; Leng, Weinan; Minarchick, Valerie; Yang, Yi; Chen, Bo; Reece, Sky W.; Brown, David A.; Cecere, Thomas E.; Brown, Jared M.; Gowdy, Kymberly M.; Hochella, Michael F. Jr.; Allen, Irving C. (Frontiers, 2019-11-28)
    Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ...
  • PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis 

    Sarraf, Shireen A.; Sideris, Dionisia P.; Giagtzoglou, Nikolaos; Artavanis-Tsakonas, Spyros; Youle, Richard J.; Pickrell, Alicia M. (Cell Press, 2019-10-01)
    PINK1 and Parkin are established mediators of mitophagy, the selective removal of damaged mitochondria by autophagy. PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations are ...
  • The genetic ancestry of American Creole cattle inferred from uniparental and autosomal genetic markers 

    Ginja, Catarina; Gama, Luis Telo; Cortes, Oscar; Martin Burriel, Inmaculada; Luis Vega-Pla, Jose; Penedo, Cecilia; Sponenberg, Phil; Canon, Javier; Sanz, Arianne; do Egito, Andrea Alves; Angela Alvarez, Luz; Giovambattista, Guillermo; Agha, Saif; Rogberg-Munoz, Andres; Cassiano Lara, Maria Aparecida; Vicente Delgado, Juan; Martinez, Amparo; Afonso, Sonia; Aguirre, Lenin; Armstrong, Eileen; Camacho Vallejo, Maria Esperanza; Canales, Amado; Cassama, Bernardo; Contreras, Gloria; Moras Cordeiro, J. M.; Dunner, Susana; Elbeltagy, Ahmed; Soares Fioravanti, Maria Clorinda; Gomez Carpio, Mayra; Gomez, Mariano; Hernandez, Antonio; Hernandez, Darwin; Juliano, Raquel Soares; Landi, Vincenzo; Marques, Ribamar; Martinez, Ruben D.; Roberto Martinez, O.; Melucci, Lilia; Molina Flores, Baldomero; Mujica, Fernando; Pares i Casanova, Pere-Miquel; Quiroz, Jorge; Rodellar, Clementina; Tjon, Gerald; Adebambo, Tumininu; Uffo, Odalys; Cesar Vargas, Julio; Villalobos, Axel; Zaragoza, Pilar (Springer Nature, 2019-08-07)
    Cattle imported from the Iberian Peninsula spread throughout America in the early years of discovery and colonization to originate Creole breeds, which adapted to a wide diversity of environments and later received influences ...
  • Formation of the Francisella tularensis Biofilm is Affected by Cell Surface Glycosylation, Growth Medium, and a Glucan Exopolysaccharide 

    Champion, Anna E.; Catanzaro, Kelly C. Freudenberger; Bandara, Aloka B.; Inzana, Thomas J. (Springer Nature, 2019-08-22)
    Biofilms are matrix-associated communities that enable bacteria to colonise environments unsuitable for free-living bacteria. The facultative intracellular pathogen Francisella tularensis can persist in water, amoebae, and ...
  • IL-12 signaling drives the differentiation and function of a T(H)1-derived T-FH1-like cell population 

    Powell, Michael D.; Read, Kaitlin A.; Sreekumar, Bharath K.; Jones, Devin M.; Oestreich, Kenneth J. (Springer Nature, 2019-09-30)
    CD4(+) T follicular helper (T-FH) cells provide help to B cells and promote antibody-mediated immune responses. Increasing evidence supports the existence of T-FH populations that secrete cytokines typically associated ...
  • Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali 

    Zambrana, Luis E.; McKeen, Starin; Ibrahim, Hend; Zarei, Iman; Borresen, Erica C.; Doumbia, Lassina; Bore, Abdoulaye; Cissoko, Alima; Douyon, Seydou; Kone, Karim; Perez, Johann; Perez, Claudia; Hess, Ann; Abdo, Zaid; Sangare, Lansana; Maiga, Ababacar; Becker-Dreps, Sylvia; Yuan, Lijuan; Koita, Ousmane; Vilchez, Samuel; Ryan, Elizabeth P. (Springer Nature, 2019-09-26)
    Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) ...
  • Virtual methylome dissection facilitated by single-cell analyses 

    Yin, Liduo; Luo, Yanting; Xu, Xiguang; Wen, Shiyu; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (2019-11-11)
    Abstract Background Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It ...
  • Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage 

    Kowalski, Elizabeth A.; Chen, Jiang; Hazy, Amanda; Fritsch, Lauren E.; Gudenschwager-Basso, Erwin K.; Chen, Michael; Wang, Xia; Qian, Yun; Zhou, Mingjun; Byerly, Matthew; Pickrell, Alicia M.; Matson, John B.; Allen, Irving C.; Theus, Michelle H. (2019-11-11)
    Abstract Background The continuum of pro- and anti-inflammatory response elicited by traumatic brain injury (TBI) is suggested to play a key role in the outcome of TBI; however, ...
  • Parenterally Administered P24-VP8* Nanoparticle Vaccine Conferred Strong Protection against Rotavirus Diarrhea and Virus Shedding in Gnotobiotic Pigs 

    Ramesh, Ashwin; Mao, Jiangdi; Lei, Shaohua; Twitchell, Erica; Shiraz, Ashton; Jiang, Xi; Tan, Ming; Yuan, and Lijuan (MDPI, 2019-11-06)
    Current live rotavirus vaccines are costly with increased risk of intussusception due to vaccine replication in the gut of vaccinated children. New vaccines with improved safety and cost-effectiveness are needed. In this ...
  • Tracing Worldwide Turkey Genetic Diversity Using D-loop Sequence Mitochondrial DNA Analysis 

    Canales Vergara, Amado Manuel; Landi, Vincenzo; Delgado Bermejo, Juan Vicente; Martínez, Amparo; Cervantes Acosta, Patricia; Pons Barro, Águeda; Bigi, Daniele; Sponenberg, Phillip; Helal, Mostafa; Hossein Banabazi, Mohammad; Camacho Vallejo, María Esperanza (MDPI, 2019-11-01)
    According to recent archeological evidence, turkey (Meleagris gallopavo gallopavo) domestication may have occurred in Mexico around 2000 years ago. However, little is known about the phylogenetic and genealogical ...
  • Co-Infection Patterns in Individual Ixodes scapularis Ticks Reveal Associations between Viral, Eukaryotic and Bacterial Microorganisms 

    Cross, Shaun T.; Kapuscinski, Marylee L.; Perino, Jacquelyn; Maertens, Bernadette L.; Lucarelli-Weger, James; Ebel, Gregory D.; Stenglein, Mark D. (MDPI, 2018-07-22)
    Ixodes scapularis ticks harbor a variety of microorganisms, including eukaryotes, bacteria and viruses. Some of these can be transmitted to and cause disease in humans and other vertebrates. Others are not pathogenic, but ...
  • Characterization of recombinant B. abortus strain RB51SOD toward understanding the uncorrelated innate and adaptive immune responses induced by RB51SOD compared to its parent vaccine strain RB51 

    Zhu, Jianguo; Larson, Charles B.; Ramaker, Megan Ann; Quandt, Kimberly; Wendte, Jered M.; Ku, Kimberly P.; Chen, Fang; Jourdian, George W.; Vemulapalli, Ramesh; Schurig, Gerhardt G.; He, Yongqun (Frontiers, 2011-11-25)
    Brucella abortus is a Gram-negative, facultative intracellular pathogen for several mammals, including humans. Live attenuated B. abortus strain RB51 is currently the official vaccine used against bovine brucellosis in the ...
  • Sibling rivalry: related bacterial small RNAs and their redundant and non-redundant roles 

    Caswell, Clayton C.; Oglesby-Sherrouse, Amanda G.; Murphy, Erin R. (Frontiers, 2014-10)
    Small RNA molecules (sRNAs) are now recognized as key regulators controlling bacterial gene expression, as sRNAs provide a quick and efficient means of positively or negatively altering the expression of specific genes. ...

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