Now showing items 61-66 of 66
JigCell Run Manager (JC-RM): a tool for managing large sets of biochemical model parametrizations
(Biomed Central Ltd, 2015-12-24)
Background Most biomolecular reaction modeling tools allow users to build models with a single list of parameter values. However, a common scenario involves different parameterizations of the model to account for the ...
Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model
(Biomed Central Ltd, 2013-06-28)
Background 'Parameter estimation from experimental data is critical for mathematical modeling of protein regulatory networks. For realistic networks with dozens of species and reactions, parameter estimation is an especially ...
A Network of SCOP Hidden Markov Models and Its Analysis
Background The Structural Classification of Proteins (SCOP) database uses a large number of hidden Markov models (HMMs) to represent families and superfamilies composed of proteins that presumably share the same evolutionary ...
Quantitative prediction of the effect of genetic variation using hidden Markov models
Background With the development of sequencing technologies, more and more sequence variants are available for investigation. Different classes of variants in the human genome have been identified, including single nucleotide ...
Predicting the combined effect of multiple genetic variants
Background Many genetic variants have been identified in the human genome. The functional effects of a single variant have been intensively studied. However, the joint effects of multiple variants in the same genes have ...