Now showing items 87-106 of 185

    • Identification of a Unique Radical S-Adenosylmethionine Methylase Likely Involved in Methanopterin Biosynthesis in Methanocaldococcus jannaschii 

      Allen, Kylie D.; Xu, Huimin; White, Robert H. (American Society for Microbiology, 2014-07-07)
      Methanopterin (MPT) and its analogs are coenzymes required for methanogenesis and methylotrophy in specialized microorganisms. The methyl groups at C-7 and C-9 of the pterin ring distinguish MPT from all other pterin-containing ...
    • Identification of aaNAT5b as a spermine N-acetyltransferase in the mosquito, Aedes aegypti 

      Guan, Huai; Wang, Maoying; Liao, Chenghong; Liang, Jing; Mehere, Prajwalini; Tian, Meiling; Liu, Hairong; Robinson, Howard; Li, Jianyong; Han, Qian (PLOS, 2018-03-19)
      Mosquitoes transmit a number of diseases in animals and humans, including Dengue, Chikungunya and Zika viruses that affect millions of people each year. Controlling the disease-transmitting mosquitoes has proven to be a ...
    • Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors 

      del Campo, Julia S. Martin; Eckshtain-Levi, Meital; Vogelaar, Nancy J.; Sobrado, Pablo (Nature, 2017-09-07)
      Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, ...
    • Identification of Early Zygotic Genes in the Yellow Fever Mosquito Aedes aegypti and Discovery of a Motif Involved in Early Zygotic Genome Activation 

      Biedler, James K.; Hu, Wanqi; Tae, Hongseok; Tu, Zhijian (PLOS, 2012-03-23)
      During early embryogenesis the zygotic genome is transcriptionally silent and all mRNAs present are of maternal origin. The maternal-zygotic transition marks the time over which embryogenesis changes its dependence from ...
    • Identification of MOS9 as an interaction partner for chalcone synthase in the nucleus 

      Watkinson, Jonathan I.; Bowerman, Peter A.; Crosby, Kevin C.; Hildreth, Sherry B.; Helm, Richard F.; Winkel, Brenda S. J. (PeerJ, 2018-09-19)
      Plant flavonoid metabolism has served as a platform for understanding a range of fundamental biological phenomena, including providing some of the early insights into the subcellular organization of metabolism. Evidence ...
    • Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii 

      Wang, Yu; Xu, Huimin; Jones, Michael K.; White, Robert H. (American Society for Microbiology, 2015-06-22)
      All methanofuran structural variants contain a basic core structure of 4-[N-(gamma -L-glutamyl)-p-(beta-aminoethyl) phenoxymethyl]( aminomethyl) furan (APMF-Glu) but have different side chains depending on the source ...
    • Implications of two different methods for analyzing total dietary fiber in foods for food composition databases 

      Phillips, Katherine M.; Haytowitz, David B.; Pehrsson, Pamela R. (2019-12)
      Since 1989, total dietary fiber values in USDA databases were determined by the enzymatic-gravimetric (EGF) method (AOAC 991.43), where "fiber" is the residue remaining after samples are subjected to enzymatic treatments ...
    • Improved reference genome of Aedes aegypti informs arbovirus vector control 

      Matthews, Benjamin J.; Dudchenko, Olga; Kingan, Sarah B.; Koren, Sergey; Antoshechkin, Igor; Crawford, Jacob E.; Glassford, William J.; Herre, Margaret; Redmond, Seth N.; Rose, Noah H.; Weedall, Gareth D.; Wu, Yang; Batra, Sanjit S.; Brito-Sierra, Carlos A.; Buckingham, Steven D.; Campbell, Corey L.; Chan, Saki; Cox, Eric; Evans, Benjamin R.; Fansiri, Thanyalak; Filipovic, Igor; Fontaine, Albin; Gloria-Soria, Andrea; Hall, Richard; Joardar, Vinita S.; Jones, Andrew K.; Kay, Raissa G. G.; Kodali, Vamsi K.; Lee, Joyce; Lycett, Gareth J.; Mitchell, Sara N.; Muehling, Jill; Murphy, Michael R.; Omer, Arina D.; Partridge, Frederick A.; Peluso, Paul; Aiden, Aviva Presser; Ramasamy, Vidya; Rasic, Gordana; Roy, Sourav; Saavedra-Rodriguez, Karla; Sharan, Shruti; Sharma, Atashi; Smith, Melissa Laird; Turner, Joe; Weakley, Allison M.; Zhao, Zhilei; Akbari, Omar S.; Black, William C.; Cao, Han; Darby, Alistair C.; Hill, Catherine A.; Johnston, J. Spencer; Murphy, Terence D.; Raikhel, Alexander S.; Sattelle, David B.; Sharakhov, Igor V.; White, Bradley J.; Zhao, Li; Aiden, Erez Lieberman; Mann, Richard S.; Lambrechts, Louis; Powell, Jeffrey R.; Sharakhova, Maria V.; Tu, Zhijian; Robertson, Hugh M.; McBride, Carolyn S.; Hastic, Alex R.; Korlach, Jonas; Neafsey, Daniel E.; Phillippy, Adam M.; Vosshall, Leslie B. (2018-11-22)
      Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and ...
    • Infrared spectroscopy of the nitrogenase MoFe protein under electrochemical control: potential-triggered CO binding 

      Paengnakorn, P.; Ash, P. A.; Shaw, S.; Danyal, K.; Chen, T.; Dean, Dennis R.; Seefeldt, Lance C.; Vincent, K. A. (Royal Society of Chemistry, 2016-10-27)
      We demonstrate electrochemical control of the nitrogenase MoFe protein, in the absence of Fe protein or ATP, using europium(III/II) polyaminocarboxylate complexes as electron transfer mediators. This allows the potential ...
    • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. 

      Lewis, Huw D.; Liddle, John; Coote, JE; Atkinson, SJ; Barker, MD; Bax, BD; Bicker, KL; Bingham, RP; Campbell, M; Chen, YH; Chung, CW; Craggs, PD; Davis, RP; Eberhard, D; Joberty, G; Lind, KE; Locke, K; Maller, C; Martinod, K; Patten, C; Polyakova, O; Rise, CE; Rüdiger, M; Sheppard, RJ; Slade, DJ; Thomas, P; Thorpe, J; Yao, G; Drewes, G; Wagner, DD; Thompson, Paul R.; Prinjha, RK; Wilson, DM (2015-03)
      PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient ...
    • Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? 

      Cridland, Caitlin; Gillaspy, Glenda (MDPI, 2020-06-17)
      The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the ...
    • Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms 

      Santolamazza, Federica; Mancini, Emiliano; Simard, Frédéric; Qi, Yumin; Tu, Zhijian; della Torre, Alessandra (Biomed Central Ltd, 2008-08-25)
      Background SINEs (Short INterspersed Elements) are homoplasy-free and co-dominant genetic markers which are considered to represent useful tools for population genetic studies, and could help clarifying the speciation ...
    • Insights into the Preservation of the Homomorphic Sex-Determining Chromosome of Aedes aegypti from the Discovery of a Male-Biased Gene Tightly Linked to the M-Locus 

      Hall, Andrew Brantley; Timoshevskiy, Vladimir A.; Sharakhova, Maria V.; Jiang, Xiaofang; Basu, Sanjay; Anderson, Michelle A. E.; Hu, Wanqi; Sharakhov, Igor V.; Adelman, Zach N.; Tu, Zhijian (Oxford Univ Press, 2014-01-01)
      The preservation of a homomorphic sex-determining chromosome in some organisms without transformation into a heteromorphic sex chromosome is a long-standing enigma in evolutionary biology. A dominant sex-determining locus ...
    • Integrated proteomic and transcriptomic analysis of the Aedes aegypti eggshell 

      Marinotti, Osvaldo; Ngo, Tuan; Kojin, Bianca B; Chou, Shao-Pei; Nguyen, Brian; Juhn, Jennifer; Carballar-Lejarazú, Rebeca; Marinotti, Pedro N; Jiang, Xiaofang; Walter, Marika F; Tu, Zhijian; Gershon, Paul D; James, Anthony A (2014-04-05)
      Background Mosquito eggshells show remarkable diversity in physical properties and structure consistent with adaptations to the wide variety of environments exploited by these insects. We applied proteomic, transcriptomic, ...
    • Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes 

      Prasad, T. S. Keshava; Mohanty, Ajeet Kumar; Kumar, Manish; Sreenivasamurthy, Sreelakshmi K.; Dey, Gourav; Nirujogi, Raja Sekhar; Pinto, Sneha M.; Madugundu, Anil K.; Pati, Arun H.; Advani, Jayshree; Manda, Srikanth S.; Gupta, Manoj Kumar; Dwivedi, Sutopa B.; Kelkar, Dhanashree S.; Hall, Brantley; Jiang, Xiaofang; Peery, Ashley; Rajagopalan, Pavithra; Yelamanchi, Soujanya D.; Solanki, Hitendra S.; Raja, Remya; Sathe, Gajanan J.; Chavan, Sandip; Verma, Renu; Patel, Krishna M.; Jain, Ankit P.; Syed, Nazia; Datta, Keshava K.; Khan, Aafaque Ahmed; Dammalli, Manjunath; Jayaram, Savita; Radhakrishnan, Aneesha; Mitchell, Christopher J.; Na, Chan-Hyun; Kumar, Nirbhay; Sinnis, Photini; Sharakhov, Igor V.; Wang, Charles; Gowda, Harsha; Tu, Zhijian; Kumar, Ashwani; Pandey, Akhilesh (2017-01)
      Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly and annotation of newly sequenced genomes. Here, we provide a proof-of-concept of an integrated approach for ...
    • Interlaboratory Trial for Measurement of Vitamin D and 25-Hydroxyvitamin D [25(OH)D] in Foods and a Dietary Supplement Using Liquid Chromatography-Mass Spectrometry 

      Roseland, Janet Maxwell; Patterson, Kristine Y.; Andrews, Karen W.; Phillips, Katherine M.; Phillips, Melissa M.; Pehrsson, Pamela R.; Dufresne, Guy L.; Jakobsen, Jette; Gusev, Pavel A.; Savarala, Sushma; Nguyen, Quynhanh V.; Makowski, Andrew J.; Scheuerell, Chad R.; Larouche, Guillaume P.; Wise, Stephen A.; Harnly, James M.; Williams, Juhi R.; Betz, Joseph M.; Taylor, Christine L. (2016-04-27)
      Assessment of total vitamin D intake from foods and dietary supplements (DSs) may be incomplete if 25-hydroxyvitamin D [25(OH)D] intake is not included. However, 25(OH)D data for such intake assessments are lacking, no ...
    • Internalization of Erythrocyte Acylpeptide Hydrolase Is Required for Asexual Replication of Plasmodium falciparum 

      Elahi, Rubayet; Dapper, Christie; Klemba, Michael (American Society for Microbiology, 2019-05-08)
      The human malaria parasite Plasmodium falciparum causes disease as it replicates within the host's erythrocytes. We have found that an erythrocyte serine hydrolase, acylpeptide hydrolase (APEH), accumulates within developing ...
    • The Juan non-LTR retrotransposon in mosquitoes: genomic impact, vertical transmission and indications of recent and wide-spread activity 

      Biedler, James K; Tu, Zhijian (2007-07-09)
      Background In contrast to DNA-mediated transposable elements (TEs), retrotransposons, particularly non-long terminal repeat retrotransposons (non-LTRs), are generally considered to have a much lower propensity towards ...
    • Juvenile hormone-regulated alternative splicing of the taiman gene primes the ecdysteroid response in adult mosquitoes 

      Liu, Pengcheng; Fu, Xiaonan; Zhu, Jinsong (NATL ACAD SCIENCES, 2018-08-14)
      Juvenile hormone (JH) regulates many aspects of insect development and reproduction. In some processes, JH plays a critical role in defining the action of the steroid hormone 20-hydroxyecdysone (20E). In Aedes aegypti ...