Now showing items 108-127 of 169

    • Molecular and Functional Characterization of Odorant-Binding Protein Genes in an Invasive Vector Mosquito, Aedes albopictus 

      Deng, Y; Yan, H; Gu, J; Xu, J; Wu, K; Tu, Z; James, AA; Chen, X (PLOS, 2013-07-23)
    • Molecular Cloning and Characterization of the First Caspase in the Striped Stem Borer, Chilo suppressalis 

      Lu, Ming-Xing; Du, Yu-Zhou; Cao, Shuang-Shuang; Liu, Pingyang; Li, Jianyong (MDPI, 2013-05-15)
      Apoptosis is executed through the activity of the caspases that are aspartyl-specific proteases. In this study, we isolated the caspase gene (Cscaspase-1) of Chilo suppressalis (one of the leading pests responsible for ...
    • Molecular dynamics simulations of the d(CCAACGTTGG)(2) decamer: Influence of the crystal environment 

      Bevan, David R.; Li, L. P.; Pedersen, L. G.; Darden, T. A. (CELL PRESS, 2000-02)
      Molecular dynamics (MD) simulations of the DNA duplex d(CCAACGTTGG)(2) were used to study the relationship between DNA sequence and structure. Two crystal simulations were carried out; one consisted of one unit cell ...
    • Motor Deficits and Decreased Striatal Dopamine Receptor 2 Binding Activity in the Striatum-Specific Dyt1 Conditional Knockout Mice 

      Yokoi, Fumiaki; Dang, Mai Tu; Li, Jianyong; Standaert, David G.; Li, Yuqing (PLOS, 2011-09-12)
      DYT1 early-onset generalized dystonia is a hyperkinetic movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Recently, significant progress has been made in studying pathophysiology of DYT1 ...
    • Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis 

      Dalloul, Rami A.; Long, JA; Zimin, AV; Aslam, L; Beal, K; Blomberg, LA; Bouffard, P; Burt, DW; Crasta, O; Crooijmans, RPMA; Cooper, K; Coulombe, RA; De, S; Delany, ME; Dodgson, JB; Dong, JJ; Evans, C; Frederickson, KM; Flicek, P; Florea, L; Folkerts, O; Groenen, MAM; Harkins, TT; Herrero, J; Hoffmann, S; Megens, H-J; Jiang, A; de Jong, P; Kaiser, P; Kim, H; Kim, K-W; Kim, S; Langenberger, D; Lee, M-K; Lee, T; Mane, S; Marcais, G; Marz, M; McElroy, AP; Modise, T; Nefedov, M; Notredame, C; Paton, IR; Payne, WS; Pertea, G; Prickett, D; Puiu, D; Qioa, D; Raineri, E; Ruffier, M; Salzberg, SL; Schatz, MC; Scheuring, C; Schmidt, CJ; Schroeder, S; Searle, SMJ; Smith, EJ; Smith, J; Sonstegard, TS; Stadler, PF; Tafer, H; Tu, ZJ; Van Tassell, CP; Vilella, AJ; Williams, KP; Yorke, JA; Zhang, L; Zhang, H-B; Zhang, X; Zhang, Y; Reed, Kent M. (PLOS, 2010-09-01)
      A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo). ...
    • Multigene Phylogenetics Reveals Temporal Diversification of Major African Malaria Vectors 

      Kamali, M; Marek, Paul E.; Peery, A; Antonio-Nkondjio, C; Ndo, C; Tu, Z; Simard, F; Sharakhov, Igor V. (PLOS, 2014-04-04)
      The major vectors of malaria in sub-Saharan Africa belong to subgenus Cellia. Yet, phylogenetic relationships and temporal diversification among African mosquito species have not been unambiguously determined. Knowledge ...
    • myo-Inositol oxygenase is required for responses to low energy conditions in Arabidopsis thaliana 

      Alford, Shannon R.; Rangarajan, Padma; Williams, Phoebe; Gillaspy, Glenda E. (Frontiers Research Foundation, 2012-01-01)
      myo-Inositol is a precursor for cell wall components, is used as a backbone of myo-inositol trisphosphate (Ins(1,4,5)P3) and phosphateidylinositol phosphate signaling molecules, and is debated about whether it is also a ...
    • N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro 

      Ballhouse, Brittany N.; Patterson, Logan; Schmelz, Eva M.; Slade, Daniel J.; Verbridge, Scott S. (PLOS, 2017-07-10)
      It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor ...
    • Natural product-based nanomedicine: recent advances and issues 

      Watkins, R; Wu, L; Zhang, C; Davis, RM; Xu, B (Dove Medical Press Ltd, 2015-01-01)
    • A New Chromosomal Phylogeny Supports the Repeated Origin of Vectorial Capacity in Malaria Mosquitoes of the Anopheles gambiae Complex 

      Kamali, M; Xia, A; Tu, Z; Sharakhov, Igor V. (PLOS, 2012-10-01)
      Understanding phylogenetic relationships within species complexes of disease vectors is crucial for identifying genomic changes associated with the evolution of epidemiologically important traits. However, the high degree ...
    • A New Role for an Old Antimicrobial: Lysozyme c-1 Can Function to Protect Malaria Parasites in Anopheles Mosquitoes 

      Kajla, Mayur K.; Shi, Lei; Li, Bin; Luckhart, Shirley; Li, Jianyong; Paskewitz, Susan M. (PLOS, 2011-05-06)
      Background Plasmodium requires an obligatory life stage in its mosquito host. The parasites encounter a number of insults while journeying through this host and have developed mechanisms to avoid host defenses. Lysozymes ...
    • Next-Generation Sequencing Reveals Recent Horizontal Transfer of a DNA Transposon between Divergent Mosquitoes 

      Diao, Yupu; Qi, Yumin; Ma, Yajun; Xia, Ai; Sharakhov, Igor V.; Chen, Xiaoguang; Biedler, James K.; Ling, Erjun; Tu, Zhijian Jake (PLOS, 2011-02-10)
      Horizontal transfer of genetic material between complex organisms often involves transposable elements (TEs). For example, a DNA transposon mariner has been shown to undergo horizontal transfer between different orders of ...
    • The NifZ accessory protein has an equivalent function in maturation of both nitrogenase MoFe protein P-clusters 

      Jimenez-Vicente, Emilio; Yang, Zhi-Yong; del Campo, Julia S. Martin; Cash, Valerie L.; Seefeldt, Lance C.; Dean, Dennis R. (2019-04-19)
      The Mo-dependent nitrogenase comprises two interacting components called the Fe protein and the MoFe protein. The MoFe protein is an (22) heterotetramer that harbors two types of complex metalloclusters, both of which are ...
    • Nitrogenase bioelectrocatalysis: heterogeneous ammonia and hydrogen production by MoFe protein 

      Milton, Ross D.; Abdellaoui, Sofiene; Khadka, Nimesh; Dean, Dennis R.; Leech, Dónal; Seefeldt, Lance C.; Minteer, Shelley D. (Royal Society of Chemistry, 2016-06-20)
      Nitrogenase is the only enzyme known to catalyze the reduction of N2 to 2NH3. In vivo, the MoFe protein component of nitrogenase is exclusively reduced by the ATP-hydrolyzing Fe protein in a series of transient ...
    • Noncanonical Reactions of Flavoenzymes 

      Sobrado, Pablo (MDPI, 2012-11-05)
      Enzymes containing flavin cofactors are predominantly involved in redox reactions in numerous cellular processes where the protein environment modulates the chemical reactivity of the flavin to either transfer one or two ...
    • De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug 

      Lancaster, Jason; Khrimian, Ashot; Young, Sharon; Lehner, Bryan; Luck, Katrin; Wallingford, Anna; Ghosh, Saikat Kumar B.; Zerbe, Philipp; Muchlinski, Andrew; Marek, Paul E.; Sparks, Michael E.; Tokuhisa, James G.; Tittiger, Claus; Koellner, Tobias G.; Weber, Donald C.; Gundersen-Rindal, Dawn E.; Kuhar, Thomas P.; Tholl, Dorothea (2018-09-11)
      Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene ...
    • Odor-Specific Daily Rhythms in the Olfactory Sensitivity and Behavior of Aedes aegypti Mosquitoes 

      Eilerts, Diane F.; VanderGiessen, Morgen; Bose, Elizabeth A.; Broxton, Kyera; Vinauger, Clément (MDPI, 2018-10-23)
      Many biological processes and behaviors in mosquitoes display rhythmic patterns, allowing for fine tuning to cyclic environmental conditions. In mosquitoes, vector-host interactions are primarily mediated by olfactory ...
    • Odorant receptor c-terminal motifs in divergent insect species 

      Miller, Raymond; Tu, Zhijian (Entomological Society of America, 2008-09-22)
      Insect odorant receptors are a large family of seven transmembrane proteins believed to be G-protein coupled receptors. The peptide sequences of two odorant receptors within a given species may share as little as 17% ...
    • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond 

      Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. (PLOS, 2016-07-28)
      A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of ...