Now showing items 1-2 of 2

    • Blastocyst Injection of Wild Type Embryonic Stem Cells Induces Global Corrections in Mdx Mice 

      Stillwell, Elizabeth; Vitale, Joseph; Zhao, Qingshi; Beck, Amanda; Schneider, Joel; Khadim, Farah; Elson, Genie; Altaf, Aneela; Yehia, Ghassan; Dong, Jia-hui; Liu, Jing; Mark, Willie; Bhaumik, Mantu; Grange, Robert; Fraidenraich, Diego (PLOS, 2009-03-11)
      Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic ...
    • Differential Requirement for Utrophin in the Induced Pluripotent Stem Cell Correction of Muscle versus Fat in Muscular Dystrophy Mice 

      Beck, Amanda J.; Vitale, Joseph M.; Zhao, Qingshi; Schneider, Joel S.; Chang, Corey; Altaf, Aneela; Michaels, Jennifer; Bhaumik, Mantu; Grange, Robert; Fraidenraich, Diego (PLOS, 2011-05-16)
      Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx∶utrophin mutant blastocysts, which are predisposed to develop DMD ...