Now showing items 21-40 of 136

    • Water transmission potential of Angiostrongylus cantonensis: Larval viability and effectiveness of rainwater catchment sediment filters 

      Howe, Kathleen; Kaluna, Lisa; Lozano, Alicia; Fischer, Bruce Torres; Tagami, Yaeko; McHugh, Robert; Jarvi, Susan (PLOS, 2019-04-25)
      Neuroangiostrongyliasis, caused by Angiostrongylus cantonensis, has been reported in Hawai'i since the 1950's. An increase in cases is being reported primarily from East Hawai'i Island, correlated with the introduction of ...
    • COREMIC: a web-tool to search for a niche associated CORE MICrobiome 

      Rodrigues, Richard R.; Rodgers, Nyle C.; Wu, Xiaowei; Williams, Mark A. (PeerJ, 2018-02-15)
      Microbial diversity on earth is extraordinary, and soils alone harbor thousands of species per, gram of soil. Understanding how this diversity is sorted and selected into habitat niches is a major focus of ecology and ...
    • Linked within-host and between-host models and data for infectious diseases: a systematic review 

      Childs, Lauren M.; El Moustaid, Fadoua; Gajewski, Zachary; Kadelka, Sarah; Nikin-Beers, Ryan; Smith, John W., Jr.; Walker, Melody; Johnson, Leah R. (PeerJ, 2019-06-19)
      The observed dynamics of infectious diseases are driven by processes across multiple scales. Here we focus on two: within-host, that is, how an infection progresses inside a single individual (for instance viral and immune ...
    • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

      Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (Springer Nature, 2019-06-12)
      The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
    • Can long-term historical data from electronic medical records improve surveillance for epidemics of acute respiratory infections? A systematic evaluation 

      Zheng, Hongzhang; Woodall, William H.; Carlson, Abigail L.; DeLisle, Sylvain (PLOS, 2018-01-31)
      Background As the deployment of electronic medical records (EMR) expands, so is the availability of long-term datasets that could serve to enhance public health surveillance. We hypothesized that EMR-based surveillance ...
    • Effect of Using Mobile Phones on Driver’s Control Behavior Based on Naturalistic Driving Data 

      Zhang, Lanfang; Cui, Boyu; Yang, Minhao; Guo, Feng; Wang, Junhua (MDPI, 2019-04-25)
      Distracted driving behaviors are closely related to crash risk, with the use of mobile phones during driving being one of the leading causes of accidents. This paper attempts to investigate the impact of cell phone use ...
    • Accurate human microsatellite genotypes from high-throughput resequencing data using informed error profiles 

      Highnam, Gareth; Franck, Christopher T.; Martin, Andy; Stephens, Calvin; Puthige, Ashwin; Mittelman, David (2013-01)
      Repetitive sequences are biologically and clinically important because they can influence traits and disease, but repeats are challenging to analyse using short-read sequencing technology. We present a tool for genotyping ...
    • XTALKDB: a database of signaling pathway crosstalk 

      Sam, Sarah A.; Teel, Joelle; Tegge, Allison N.; Bharadwaj, Aditya; Murali, T. M. (2017-01-04)
      Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents ...
    • Two-phase Monte Carlo simulation for partitioning the effects of epistemic and aleatory uncertainty in TMDL modeling 

      Mishra, A.; Ahmadisharaf, E.; Benham, B.L.; Gallagher, D.L.; Reckhow, K.H.; Smith, E. P. (American Society of Civil Engineers (ASCE), 2018-10-29)
      A two-phase Monte Carlo simulation (TPMCS) uncertainty analysis framework is used to analyze epistemic and aleatory uncertainty associated with simulated exceedances of an in-stream fecal coliform (FC) water quality criterion ...
    • Profile monitoring based quality control method for fused deposition modeling process 

      He, K.; Zhang, Q.; Hong, Y. (Springer New York LLC, 2018-05-26)
      In order to monitor the quality of parts in printing, the methodology to monitor the geometric quality of the printed parts in fused deposition modeling process is researched. A non-contact measurement method based on ...
    • Panamanian frog species host unique skin bacterial communities 

      Belden, Lisa K.; Hughey, Myra C.; Rebollar, Eria A.; Umile, Thomas P.; Loftus, Stephen C.; Burzynski, Elizabeth A.; Minbiole, Kevin P. C.; House, Leanna L.; Jensen, Roderick V.; Becker, Matthew H.; Walke, Jenifer B.; Medina, Daniel; Ibanez, Roberto; Harris, Reid N. (Frontiers, 2015-10-27)
      Vertebrates, including amphibians, host diverse symbiotic microbes that contribute to host disease resistance. Globally, and especially in montane tropical systems, many amphibian species are threatened by a chytrid fungus, ...
    • System and method for genotyping using informed error profiles 

      Virginia Tech Intellectual Properties, Inc.; Mittelman, David A.; Franck, Christopher T. (United States Patent and Trademark Office, 2018-03-13)
      A system and method for genotyping tandem repeats in sequencing data. The invention uses Bayesian model selection guided by an empirically-derived error model that incorporates properties of sequence reads and reference ...
    • vi-HMM: a novel HMM-based method for sequence variant identification in short-read data 

      Tang, Man; Hasan, Mohammad Shabbir; Zhu, Hongxiao; Zhang, Liqing; Wu, Xiaowei (2019-02-13)
      Abstract Background Accurate and reliable identification of sequence variants, including single nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms (INDELs), ...
    • Age-related variations in the methylome associated with gene expression in human monocytes and T cells 

      Reynolds, Lindsay M.; Taylor, Jackson R.; Ding, Jingzhong; Lohman, Kurt; Johnson, Craig; Siscovick, David; Burke, Gregory L.; Post, Wendy; Shea, Steven; Jacobs, David R., Jr.; Stunnenberg, Hendrik G.; Kritchevsky, Stephen B.; Hoeschele, Ina; McCall, Charles E.; Herrington, David M.; Tracy, Russell P.; Liu, Yongmei (Springer Nature, 2014-11)
      Age-related variations in DNA methylation have been reported; however, the functional relevance of these differentially methylated sites (age-dMS) are unclear. Here we report potentially functional age-dMS, defined as ...
    • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis 

      Liu, Yongmei; Reynolds, Lindsay M.; Ding, Jingzhong; Hou, Li; Lohman, Kurt; Young, Tracey; Cui, Wei; Huang, Zhiqing; Grenier, Carole; Wan, Ma; Stunnenberg, Hendrik G.; Siscovick, David; Hou, Lifang; Psaty, Bruce M.; Rich, Stephen S.; Rotter, Jerome I.; Kaufman, Joel D.; Burke, Gregory L.; Murphy, Susan; Jacobs, David R., Jr.; Post, Wendy; Hoeschele, Ina; Bell, Douglas A.; Herrington, David M.; Parks, John S.; Tracy, Russell P.; McCall, Charles E.; Stein, James H. (Springer Nature, 2017-08-30)
      Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes ...
    • The effect of temporal aggregation level in social network monitoring 

      Zhao, Meng J.; Driscoll, Anne R.; Sengupta, Srijan; Stevens, Nathaniel T.; Fricker, Ronald D. Jr.; Woodall, William H. (PLOS, 2018-12-19)
      Social networks have become ubiquitous in modern society, which makes social network monitoring a research area of significant practical importance. Social network data consist of social interactions between pairs of ...
    • Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma 

      Connolly, Nina P.; Shetty, Amol C.; Stokum, Jesse A.; Hoeschele, Ina; Siegel, Marni B.; Miller, C. Ryan; Kim, Anthony J.; Ho, Cheng-Ying; Davila, Eduardo; Simard, J. Marc; Devine, Scott E.; Rossmeisl, John H.; Holland, Eric C.; Winkles, Jeffrey A.; Woodworth, Graeme F. (Springer Nature, 2018-01-19)
      Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis ...
    • Cell Cycle Model System for Advancing Cancer Biomarker Research 

      Lazar, Iulia M.; Hoeschele, Ina; de Morais, Juliana; Tenga, Milagros J. (Springer Nature, 2017-12-21)
      Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. ...
    • Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models 

      Tegge, Allison N.; Rodrigues, Richard R.; Larkin, Adam L.; Vu, Lucas; Murali, T. M.; Rajagopalan, Padmavathy (Springer Nature, 2018-07-27)
      Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ...
    • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

      Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
      Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...