Browsing Scholarly Works, Department of Biomedical Sciences and Pathobiology by Title
Now showing items 250-269 of 328
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A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications
(Taylor & Francis Inc, 2015-03-01)The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed ... -
Rapid virulence prediction and identification of Newcastle disease virus genotypes using third-generation sequencing
(2018-11-22)Abstract Background Newcastle disease (ND) outbreaks are global challenges to the poultry industry. Effective management requires rapid identification and virulence prediction ... -
Re-Evaluation of Asynchronous Asexual Development of Cystoisospora canis in Intestines of Dogs
(2019-01-28)The coccidian parasite Cystoisospora canis (syn. Isospora canis) can cause clinical disease in dogs. Three generation of schizonts have been reported in the small intestine of dogs before oocysts are excreted 9-11 days ... -
Real-time prediction of patient immune cell modulation during irreversible electroporation therapy
(2019-11-28)Immunotherapies have demonstrated limited efficacy in pancreatic ductal adenocarcinoma (PDAC) patients despite their success in treating other tumor types. This limitation is largely due to the relatively immunosuppressive ... -
Recent advances in Brucella abortus vaccines
(2015-07-08)Brucella abortus vaccines play a central role in bovine brucellosis control/eradication programs and have been successfully used worldwide for decades. Strain 19 and RB51 are the approved B. abortus vaccines strains most ... -
Regulation of Cytoskeleton Organization by Sphingosine in a Mouse Cell Model of Progressive Ovarian Cancer
(MDPI, 2013-07-16)Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer progression are not well established. We have previously reported the dysregulation of the cytoskeleton during ovarian cancer progression ... -
Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
(Frontiers, 2015-07-14)In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits ... -
Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?
(MDPI, 2012-05-01)Regulatory T cells (Tregs) are a subset of T cells that are responsible for maintaining peripheral immune tolerance and homeostasis. The hallmark of Tregs is the expression of the forkhead box P3 ... -
Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway
(Frontiers, 2017-01-18)Current antifungal therapies have limited effectiveness in treating invasive fungal infections. Furthermore, the development of new antifungal is currently unable to keep pace with the urgent demand for safe and effective ... -
Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
(Nature Publishing Group, 2020-05-05)The limited number of antifungals and the rising frequency of azole-resistant Candida species are growing challenges to human medicine. Drug repurposing signifies an appealing approach to enhance the activity of current ... -
Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci
(Nature Publishing Group, 2018-05-29)Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant enterococci (VRE), are among the pathogens that require new antibiotic innovation. The colonization of the gut represents a major pathway by which ... -
Repurposing celecoxib as a topical antimicrobial agent
(Frontiers, 2015-07-28)There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and ... -
Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens
(PLoS, 2015-07-29)Without a doubt, our current antimicrobials are losing the battle in the fight against newly-emerged multidrug-resistant pathogens. There is a pressing, unmet need for novel antimicrobials and novel approaches to develop ... -
Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE)
(PLoS, 2018-06-28)Enterococci represent one of the microbial world’s most challenging enigmas. Colonization of the gastrointestinal tract (GIT) of high-risk/immunocompromised patients by enterococci exhibiting resistance to vancomycin (VRE) ... -
Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
(Nature Publishing Group, 2015-06-26)Novel antimicrobials and new approaches to developing them are urgently needed. Repurposing already-approved drugs with well-characterized toxicology and pharmacology is a novel way to reduce the time, cost, and risk ... -
Restricted Enzooticity of Hepatitis E Virus Genotypes 1 to 4 in the United States
(American Society for Microbiology, 2011-10-12)Hepatitis E is recognized as a zoonosis, and swine are known reservoirs, but how broadly enzootic its causative agent, hepatitis E virus (HEV), is remains controversial. To determine the prevalence of HEV infection in ... -
Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus
(2019-02-14)Abstract DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in ... -
Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus
(2020-03-20)We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity are unknown. Here, ... -
Retinoic Acid, Leaky Gut, and Autoimmune Diseases
(MDPI, 2018-08-03)A leaky gut has been observed in a number of autoimmune diseases including type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus erythematosus. Previous studies from our laboratory have shown ...
