Now showing items 117-136 of 298

    • HDP - A novel heme detoxification protein from the malaria parasite 

      Dewal, Jani; Nagarkatti, Rana; Beatty, Wandy; Angel, Ross; Slebodnick, Carla; Anderson, John; Kumar, Sanjai; Rathore, Dharmendar (Public Library of Science, 2008-04-25)
      When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification ...
    • Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism 

      Bassaganya-Riera, Josep; Dominguez-Bello, Maria Gloria; Kronsteiner, Barbara; Carbo, Adria; Pinyi, Lu; Viladomiu, Monica; Pedragosa, Mireia; Zhang, Xiaoying; Sobral, Bruno W.; Mane, Shrinivasrao P.; Mohapatra, Saroj K.; Horne, William T.; Guri, Amir J.; Groeschl, Michael; Lopez-Velasco, Gabriela; Hontecillas, Raquel (Public Library of Science, 2012-11-15)
      Background: There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. ...
    • High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid 

      Hendrickson, Ronald C.; Lee, Anita Y.H.; Song, Qinghua; Liaw, Andy; Winer, Matt; Paweletz, Cloud P.; Seeburger, Jeffrey L.; Li, Jenny; Meng, Fanyu; Deyanova, Ekaterina G.; Mazur, Matthew T.; Settlage, Robert E.; Zhao, Xuemei; Southwick, Katie; Du, Yi; Holder, Dan; Sachs, Jeffrey R.; Laterza, Omar F.; Dallob, Aimee; Chappell, Derek L.; Snyder, Karen; Modur, Vijay; King, Elizabeth; Joachim, Catharine; Bondarenko, Andrey Y.; Shearman, Mark; Soper, Keith A.; Smith, A. David; Potter, William Z.; Koblan, Ken S.; Sachs, Alan B.; Yates, Nathan A. (PLOS, 2015-08-13)
      Disease modifying treatments for Alzheimer’s disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive ...
    • High-performance biocomputing for simulating the spread of contagion over large contact networks 

      Bisset, Keith R.; Aji, Ashwin M.; Marathe, V. Madhav; Feng, Wu-Chun (BMC Genomics, 2012-04-12)
      Background Many important biological problems can be modeled as contagion diffusion processes over interaction networks. This article shows how the EpiSimdemics interaction-based simulation system can be applied to the ...
    • Human Initiated Cascading Failures in Societal Infrastructures 

      Barrett, Christopher L.; Channakeshava, Karthik; Huang, Fei; Marathe, Achla; Marathe, Madhav V.; Pei, Guanhong; Saha, Sudip; Vullikanti, Anil Kumar S.; Kim, Junwhan; Subbiah, Balaaji S. P. (Public Library of Science, 2012-10-31)
      In this paper, we conduct a systematic study of human-initiated cascading failures in three critical inter-dependent societal infrastructures due to behavioral adaptations in response to a crisis. We focus on three closely ...
    • The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pesti 

      Dye, Matthew D.; Neff, Chris; Dufford, Max; Rivera, Corban G.; Shattuck, Donna; Bassaganya-Riera, Josep; Murali, T. M.; Sobral, Bruno W. (Public Library of Science, 2010-08-09)
      Background: Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category ...
    • Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus 

      Dai, Rujuan; Zhang, Yan; Khan, Deena; Heid, Bettina; Caudell, David; Crasta, Oswald; Ahmed, S. Ansar (PLOS, 2010-12-10)
      Background Recent reports have shown that microRNAs (miRNAs) regulate vital immunological processes and have emerged as key regulators of immune system development and function. Therefore, it is important to determine ...
    • Identification of a Polyketide Synthase Required for Alternariol (AOH) and Alternariol-9-Methyl Ether (AME) Formation in Alternaria alternata 

      Saha, Debjani; Fetzner,Ramona; Burkhardt, Britta; Podlech, Joachim; Metzler, Manfred; Dang, Ha; Lawrence, Christopher; Fischer, Reinhard (PLoS ONE, 2012-07-06)
      Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds ...
    • Identification of Early Zygotic Genes in the Yellow Fever Mosquito Aedes aegypti and Discovery of a Motif Involved in Early Zygotic Genome Activation 

      Biedler, James K.; Hu, Wanqi; Tae, Hongseok; Tu, Zhijian (PLOS, 2012-03-23)
      During early embryogenesis the zygotic genome is transcriptionally silent and all mRNAs present are of maternal origin. The maternal-zygotic transition marks the time over which embryogenesis changes its dependence from ...
    • Identification of new genes in Sinorhizobium meliloti using the Genome Sequencer FLX system 

      Mao, Chunhong; Evans, Clive; Jensen, Roderick V; Sobral, Bruno WS (2008-05-02)
      Background Sinorhizobium meliloti is an agriculturally important model symbiont. There is an ongoing need to update and improve its genome annotation. In this study, we used a high-throughput pyrosequencing approach to ...
    • Immunoregulatory Actions of Epithelial Cell PPAR γ at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease 

      Mohapatra, Saroj K.; Guri, Amir J.; Climent, Montse; Vives, Cristina; Carbo, Adria; Horne, William T.; Hontecillas, Raquel; Bassaganya-Riera, Josep (Public Library of Science, 2010-04-20)
      Background: Peroxisome proliferator-activated receptors are nuclear receptors highly expressed in intestinal epithelial cells (IEC) and immune cells within the gut mucosa and are implicated in modulating inflammation and ...
    • Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria 

      Bassaganya-Riera, Josep; Viladomiu, Monica; Pedragosa, Mireia; De Simone, Claudio; Hontecillas, Raquel (Public Library of Science, 2012-04-12)
      Background: Inflammatory bowel disease (IBD) increases the risk of colorectal cancer. Probiotic bacteria produce immunoregulatory metabolites in vitro such as conjugated linoleic acid (CLA), a polyunsaturated fatty acid ...
    • Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex 

      Gross, Fridolin; Bonaiuti, Paolo; Hauf, Silke; Ciliberto, Andrea (PLOS, 2018-09-10)
      The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex (APC/C) and its ...
    • Improvements to PATRIC, the all-bacterial Bioinformatics Database and Analysis Resource Center 

      Wattam, Alice R.; Davis, James J.; Assaf, Rida; Boisvert, Sebastien; Brettin, Thomas; Bun, Christopher; Conrad, Neal; Dietrich, Emily M.; Disz, Terry; Gabbard, Joseph L.; Gerdes, Svetlana; Henry, Christopher S.; Kenyon, Ronald W.; Machi, Dustin; Mao, Chunhong; Nordberg, Eric K.; Olsen, Gary J.; Murphy-Olson, Daniel E.; Olson, Robert; Overbeek, Ross; Parrello, Bruce; Pusch, Gordon D.; Shukla, Maulik; Vonstein, Veronika; Warren, Andrew; Xia, Fangfang; Yoo, Hyunseung; Stevens, Rick L. (2017-01-04)
      The Pathosystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center (https://www.patricbrc.org). Recent changes to PATRIC include a redesign of the web interface and some new services that ...
    • Infection and genotype remodel the entire soybean transcriptome 

      Zhou, Lecong; Mideros, Santiago X.; Bao, Lei; Hanlon, Regina; Arredondo, Felipe D.; Tripathy, Sucheta; Krampis, Konstantinos; Jerauld, Adam; Evans, Clive; St Martin, Steven K.; Maroof, M. A. Saghai; Hoeschele, Ina; Dorrance, Anne E.; Tyler, Brett M. (2009-01-26)
      Background High throughput methods, such as high density oligonucleotide microarray measurements of mRNA levels, are popular and critical to genome scale analysis and systems biology. However understanding the results of ...
    • Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active anti proliferative and tumor cell differentiation agent 

      Strobl, J. S.; Seibert, C. W.; Li, Y. B.; Nagarkatti, R.; Mitchell, S. M.; Rosypal, A. C.; Rathore, D.; Lindsay, D. S. (American Society of Parasitology, 2009-02)
      We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for ...
    • Inhibitory Role of Notch1 in Calcific Aortic Valve Disease 

      Acharya, Asha; Hans, Chetan P.; Koenig, Sara N.; Nichols, Haley A.; Galindo, Cristi L.; Garner, Harold R.; Merrill, Walter H.; Hinton, Robert B; Garg, Vidu (PLoS ONE, 2011-11-16)
      Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and ...
    • Innovation networks and social contagion in East Africa 

      Gunter, J.; Rivers, C.; Eubank, S.; Moore, Keith M.; Kuhlman, C.; Lamb, Jennifer N.; Norton, James; Omondi, E.; Ojok, R.L.; Sikuku, D.N.; Ashilenje, Dennis S.; Odera, J. (2012)
      This study seeks to understand the pathway by which new technology and the associated knowledge passes through community networks in western Kenya and eastern Uganda. Previous research in the region emphasizes the importance ...
    • Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species 

      Oliveira, Alberto; Oliveira, Leticia C.; Aburjaile, Flavia; Benevides, Leandro; Tiwari, Sandeep; Jamal, Syed B.; Silva, Arthur; Figueiredo, Henrique C. P.; Ghosh, Preetam; Portela, Ricardo W.; De Carvalho Azevedo, Vasco A.; Wattam, Alice R. (Frontiers, 2017-10-12)
      This review gathers recent information about genomic and transcriptomic studies in the Corynebacterium genus, exploring, for example, prediction of pathogenicity islands and stress response in different pathogenic and ...
    • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

      Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
      Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...