Now showing items 318-323 of 323

    • What Can We Learn from Global Sensitivity Analysis of Biochemical Systems? 

      Kent, Edward; Neumann, Stefan; Kummer, Ursula; Mendes, Pedro (PLOS, 2013-09-14)
      Most biological models of intermediate size, and probably all large models, need to cope with the fact that many of their parameter values are unknown. In addition, it may not be possible to identify these values unambiguously ...
    • What Factors Might Have Led to the Emergence of Ebola in West Africa? 

      Alexander, Kathleen A.; Sanderson, Claire E.; Marathe, Madav; Lewis, Bryan L.; Rivers, Caitlin M.; Lofgren Eric; Eubank, Stephen; et al. (PLOS, 2015-06-04)
      An Ebola outbreak of unprecedented scope emerged in West Africa in December 2013 and presently continues unabated in the countries of Guinea, Sierra Leone, and Liberia. Ebola is not new to Africa, and outbreaks have been ...
    • What to know before forecasting the flu 

      Chakraborty, Prithwish; Lewis, Bryan; Eubank, Stephen; Brownstein, John S.; Marathe, Madhav; Ramakrishnan, Naren (PLOS, 2018-10-12)
      Accurate and timely influenza (flu) forecasting has gained significant traction in recent times. If done well, such forecasting can aid in deploying effective public health measures. Unlike other statistical or machine ...
    • Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons 

      Hixson, James E.; Jun, Goo; Shimmin, Lawrence C.; Wang, Yizhi; Yu, Guoqiang; Mao, Chunhong; Warren, Andrew S.; Howard, Timothy D.; Vander Heide, Richard S.; Van Eyk, Jennifer; Wang, Yue; Herrington, David M. (Springer Nature, 2017-06-22)
      We investigated the influence of genetic variants on atherosclerosis using whole exome sequencing in cases and controls from the autopsy study "Pathobiological Determinants of Atherosclerosis in Youth (PDAY)". We identified ...
    • Writing DNA with GenoCAD (TM) 

      Czar, Michael J.; Cai, Yizhi; Peccoud, Jean (2009-07-01)
      Chemical synthesis of custom DNA made to order calls for software streamlining the design of synthetic DNA sequences. GenoCAD (TM) (www.genocad.org) is a free web-based application to design protein expression vectors, ...
    • Zoospore interspecific signaling promotes plant infection by Phytophthora 

      Kong, P; Tyler, BM; Richardson, PA; Lee, BWK; Zhou, ZS; Hong, C (Biomed Central Ltd, 2010-12-07)
      Background Oomycetes attack a huge variety of economically and ecologically important plants. These pathogens release, detect and respond to signal molecules to coordinate their communal behaviors including the infection ...