Browsing Research Articles (BI) by Title
Now showing items 1-20 of 177
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A Network Biology Approach to Denitrification in Pseudomonas aeruginosa
(2015-02-23)Pseudomonas aeruginosa is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, P. aeruginosa can perform (complete) denitrification, a respiratory process of ... -
A Simulation Optimization Approach to Epidemic Forecasting
(PLOS, 2013-06-27)Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents ... -
Accuracy of epidemiological inferences based on publicly available information: retrospective comparative analysis of line lists of human cases infected with influenza A(H7N9) in China
(2014-05-28)Background Appropriate public health responses to infectious disease threats should be based on best-available evidence, which requires timely reliable data for appropriate analysis. During the early stages of epidemics, ... -
ADAM: Analysis of Discrete Models of Biological Systems Using Computer Algebra
(2011-07-20)Background Many biological systems are modeled qualitatively with discrete models, such as probabilistic Boolean networks, logical models, Petri nets, and agent-based models, to gain a better understanding of them. The ... -
An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
(Public Library of Science, 2009-01-09)Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-gamma hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA ... -
Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype
(Nature Publishing Group, 2014-05)Karyotypic diversification is more prominent in Equus species than in other mammals. Here, using next generation sequencing technology, we generated and de novo assembled quality genomes sequences for a male wild horse ... -
Analysis of Microsatellite Variation in Drosophila melanogaster with Population-Scale Genome Sequencing. PLoS One. 2012;7:12.
(PLoS ONE, 2012-03-12)Genome sequencing technologies promise to revolutionize our understanding of genetics, evolution, and disease by making it feasible to survey a broad spectrum of sequence variation on a population scale. However, this ... -
Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions
(2007-11-08)Background: Schistosoma mansoni is a blood helminth parasite that causes schistosomiasis, a disease that affects 200 million people in the world. Many orthologs of known mammalian genes have been discovered in this parasite ... -
Analysis of tall fescue ESTs representing different abiotic stresses, tissue types and developmental stages
(2008-03-04)Background Tall fescue (Festuca arundinacea Schreb) is a major cool season forage and turf grass species grown in the temperate regions of the world. In this paper we report the generation of a tall fescue expressed sequence ... -
An anomalous type IV secretion system in Rickettsia is evolutionarily conserved
(Public Library of Science, 2009-03-12)Background: Bacterial type IV secretion systems (T4SSs) comprise a diverse transporter family functioning in conjugation, competence, and effector molecule (DNA and/or protein) translocation. Thirteen genome sequences from ... -
An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity
(2013-02-12)Background Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ... -
Bayesian estimation of genetic parameters for multivariate threshold and continuous phenotypes and molecular genetic data in simulated horse populations using Gibbs sampling
(2007-05-09)Background Requirements for successful implementation of multivariate animal threshold models including phenotypic and genotypic information are not known yet. Here simulated horse data were used to investigate the properties ... -
BioFlow: a web based workflow management software for design and execution of genomics pipelines
(2014-09-18)Background Bioinformatics data analysis is usually done sequentially by chaining together multiple tools. These are created by writing scripts and tracking the inputs and outputs of all stages. Writing such scripts require ... -
Brucella melitensis VjbR and C12-HSL regulons: contributions of the N-dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression
(2010-06-08)Background Quorum sensing is a communication system that regulates gene expression in response to population density and often regulates virulence determinants. Deletion of the luxR homologue vjbR highly attenuates ... -
Building Capacity for Data Driven Governance - Creating a New Foundation for Democracy
Existing data flows at the local level, public and administrative records, geospatial data, social media, surveys, as well as other federal, state, and local databases, are ubiquitous in our everyday life. These data, when ... -
Can Administrative Housing Data Replace Survey Data?
(HUD, 2017)This article examines the feasibility of using local administrative data sources for enhancing and supplementing federally collected survey data to describe housing in Arlington County, Virginia. Using real estate assessment ... -
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study
(PLOS, 2013-06-18)Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. We used Illumina® Next Generation Sequencing (NGS) technology to gain unbiased biological ... -
Common and contrasting themes in host cell-targeted effectors from bacterial, fungal, oomycete and nematode plant symbionts described using the Gene Ontology
(2009-02-19)A wide diversity of plant-associated symbionts, including microbes, produce proteins that can enter host cells, or are injected into host cells in order to modify the physiology of the host to promote colonization. These ... -
Common themes in nutrient acquisition by plant symbiotic microbes, described by the Gene Ontology
(2009-02-19)A critical function for symbionts is the acquisition of nutrients from their host. Relationships between hosts and symbionts range from biotrophic mutualism to necrotrophic parasitism, with a corresponding range of structures ... -
Comparative genomic analysis and phylogenetic position of Theileria equi
(2012-11-09)Background Transmission of arthropod-borne apicomplexan parasites that cause disease and result in death or persistent infection represents a major challenge to global human and animal health. First described in 1901 as ...
