Virginia Tech
    • Log in
    View Item 
    •   VTechWorks Home
    • College of Science (COS)
    • Department of Mathematics
    • Scholarly Works, Department of Mathematics
    • View Item
    •   VTechWorks Home
    • College of Science (COS)
    • Department of Mathematics
    • Scholarly Works, Department of Mathematics
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Stabilizing gene regulatory networks through feedforward loops

    Thumbnail
    View/Open
    Main article (424.2Kb)
    Downloads: 410
    Date
    2013-06
    Author
    Kadelka, Claus Thomas
    Murrugarra, David
    Laubenbacher, Reinhard C.
    Metadata
    Show full item record
    Abstract
    The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has been identified as the action of so-called microRNAs that operate via feedforward loops. We present results of a computational study, using the modeling framework of stochastic Boolean networks, which explores the role that such network motifs play in stabilizing global dynamics. The paper introduces a new measure for the stability of stochastic networks. The results show that certain types of feedforward loops do indeed buffer the network against stochastic effects.
    URI
    http://hdl.handle.net/10919/24398
    Collections
    • Scholarly Works, Department of Mathematics [289]

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us
     

     

    VTechWorks

    AboutPoliciesHelp

    Browse

    All of VTechWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Log inRegister

    Statistics

    View Usage Statistics

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us