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  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond 

    Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. (PLOS, 2016-07-28)
    A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of ...
  • Antiproliferative triterpenoid saponins from Leptaulus citroides Baill. from the Madagascar rain forest 

    Su, Q; Brodie, PJ; Liu, Y; Miller, JS; Andrianjafy, NM; Antsiferana, R; Rasamison, VE; Kingston, DGI (Springer, 2016)
  • Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp. 

    Rasamison, VE; Rakotondraibe, LH; Slebodnick, C; Brodie, PJ; Ratsimbason, M; TenDyke, K; Shen, Y; Randrianjanaka, LM; Kingston, DGI (Amer Chemical Soc, 2014-05-16)
  • The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent 

    Kingston, DGI; Snyder, JP (Amer Chemical Soc, 2014-08-01)
  • Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest 

    Liu, Y; Young, K; Rakotondraibe, LH; Brodie, PJ; Wiley, JD; Cassera, MB; Callmander, MW; Rakotondrajaona, R; Rakotobe, E; Rasarnison, VE; TenDyke, K; Shen, Y; Kingston, DGI (Amer Chemical Soc, 2015-07-01)
  • Antimalarial 5,6-Dihydro-alpha-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-alpha-Pyrones Are Artifacts 

    Liu, Y; Rakotondraibe, H; Brodie, PJ; Wiley, JD; Cassera, MB; Miller, JS; Ratovoson, F; Rakotobe, E; Rasamison, VE; Kingston, DGI (Amer Chemical Soc, 2015-06-01)
  • Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit 

    Slade, DJ; Lovelace, LL; Chruszcz, M; Minor, W; Lebioda, L; Sodetz, JM (Academic Press Ltd Elsevier Science Ltd, 2008-05-29)
  • Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation 

    Zhang, X; Bolt, M; Guertin, MJ; Chen, W; Zhang, S; Cherrington, BD; Slade, DJ; Dreyton, CJ; Subramanian, V; Bicker, KL; Thompson, PR; Mancini, MA; Lis, JT; Coonrod, SA (2012-08-14)
  • Chemical and Biological Methods to Detect Post-Translational Modifications of Arginine 

    Slade, DJ; Subramanian, V; Fuhrmann, J; Thompson, PR (2014-02)
  • Citrulination unravels stem cells 

    Slade, DJ; Subramanian, V; Thompson, PR (2014-05)
  • Chemical Proteomic Platform To Identify Citrullinated Proteins 

    Lewallen, DM; Bicker, KL; Subramanian, V; Clancy, KW; Slade, DJ; Martell, J; Dreyton, CJ; Sokolove, J; Weerapana, E; Thompson, PR (2015-11-20)
  • Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design 

    Slade, DJ; Fang, P; Dreyton, CJ; Zhang, Y; Fuhrmann, J; Rempel, D; Bax, BD; Coonrod, SA; Lewis, HD; Guo, M; Gross, ML; Thompson, PR (Amer Chemical Soc, 2015-04-01)
  • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. 

    Lewis, HD; Liddle, J; Coote, JE; Atkinson, SJ; Barker, MD; Bax, BD; Bicker, KL; Bingham, RP; Campbell, M; Chen, YH; Chung, CW; Craggs, PD; Davis, RP; Eberhard, D; Joberty, G; Lind, KE; Locke, K; Maller, C; Martinod, K; Patten, C; Polyakova, O; Rise, CE; Rüdiger, M; Sheppard, RJ; Slade, DJ; Thomas, P; Thorpe, J; Yao, G; Drewes, G; Wagner, DD; Thompson, PR; Prinjha, RK; Wilson, DM (2015-03)
    PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient ...
  • Activation of PAD4 in NET formation. 

    Rohrbach, AS; Slade, DJ; Thompson, PR; Mowen, KA (2012)
    Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in granulocytes and is essential for the formation ...
  • Genetic Reporter System for Positioning of Proteins at the Bacterial Pole 

    Fixen, KR; Janakiraman, A; Garrity, S; Slade, DJ; Gray, AN; Karahan, N; Hochschild, A; Goldberg, MB (2012)
  • HIV-1 drug discovery: targeting folded RNA structures with branched peptides 

    Wynn, Jessica E.; Santos, Webster L. (The Royal Society of Chemistry, 2015-04-28)
    Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy ...
  • Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) 

    Karpin, George W.; Morris, David M; Ngo, Mai T; Merola, Joseph S.; Falkinham, Joseph O. (Royal Society of Chemistry, 2015-06)
    Pentaalkylcyclopentadienyl (Cp*R) iridium (Ir) and cobalt (Co) 1,2-diamine complexes were synthesized. Susceptibility of Staphylococcus aureus and recent patient methicillin-resistant S. aureus (MRSA) isolates to the ...
  • Learning Chemistry from Bacteria 

    Clardy, Jon (2013-12-17)
    Dr. Jon Clardy Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University All animals, including humans, originated and evolved on a planet already teeming with bacteria, and ...