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dc.contributor.authorZhang, Shuaien_US
dc.contributor.authorHulver, Matthew W.en_US
dc.contributor.authorMcMillan, Ryan P.en_US
dc.contributor.authorCline, Mark A.en_US
dc.contributor.authorGilbert, Elizabeth R.en_US
dc.identifier.citationNutrition & Metabolism. 2014 Feb 12;11(1):10en_US
dc.description.abstractMetabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response to nutritional state depends on the genetically influenced balance between oxidation and storage capacities. Competition between fatty acids and glucose for oxidation occurs at the level of the pyruvate dehydrogenase complex (PDC). The PDC is normally active in most tissues in the fed state, and suppressing PDC activity by pyruvate dehydrogenase (PDH) kinase (PDK) is crucial to maintain energy homeostasis under some extreme nutritional conditions in mammals. Conversely, inappropriate suppression of PDC activity might promote the development of metabolic diseases. This review summarizes PDKs’ pivotal role in control of metabolic flexibility under various nutrient conditions and in different tissues, with emphasis on the best characterized PDK4. Understanding the regulation of PDC and PDKs and their roles in energy homeostasis could be beneficial to alleviate metabolic inflexibility and to provide possible therapies for metabolic diseases, including type 2 diabetes (T2D).en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.titleThe pivotal role of pyruvate dehydrogenase kinases in metabolic flexibilityen_US
dc.typeArticle - Refereeden_US
dc.description.versionPeer Reviewed
dc.rights.holderShuai Zhang et al.; licensee BioMed Central Ltd.en_US
dc.contributor.departmentAnimal and Poultry Sciencesen_US
dc.title.serialNutrition & Metabolism

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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International