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dc.contributorVirginia Tech
dc.contributor.authorTyson, John J.
dc.contributor.authorHong, C. I.
dc.contributor.authorThron, C. D.
dc.contributor.authorNovak, B.
dc.date.accessioned2014-02-26T19:10:04Z
dc.date.available2014-02-26T19:10:04Z
dc.date.issued1999-11
dc.identifier.citationTyson, JJ; Hong, CI; Thron, CD; et al., "A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM," Biophysical Journal 77(5), 2411-2417 (1999); doi: 10.1016/s0006-3495(99)77078-5
dc.identifier.issn0006-3495
dc.identifier.urihttp://hdl.handle.net/10919/25768
dc.description.abstractMany organisms display rhythms of physiology and behavior that are entrained to the 24-h cycle of light and darkness prevailing on Earth. Under constant conditions of illumination and temperature, these internal biological rhythms persist with a period close to 1 day("circadian"), but it is usually not exactly 24 h. Recent discoveries have uncovered stunning similarities among the molecular circuitries of circadian clocks in mice, fruit flies, and bread molds. A consensus picture is coming into focus around two proteins (called PER and TIM in fruit flies), which dimerize and then inhibit transcription of their own genes. Although this picture seems to confirm a venerable model of circadian rhythms based on time-delayed negative feedback, we suggest that just as crucial to the circadian oscillator is a positive feedback loop based on stabilization of PER upon dimerization. These ideas can be expressed in simple mathematical form(phase plane portraits), and the model accounts naturally for several hallmarks of circadian rhythms, including temperature compensation and the per(L) mutant phenotype. In addition, the model suggests how an endogenous circadian oscillator could have evolved from a more primitive, light-activated switch.
dc.description.sponsorshipHoward Hughes Medical Institute 75195-512302
dc.description.sponsorshipNational Science Foundation DMS-9525766
dc.language.isoen_US
dc.publisherCELL PRESS
dc.subjectdrosophila clock gene
dc.subjecttemperature-compensation
dc.subjectperiod protein
dc.subjecttimeless
dc.subjecttranscription
dc.subjectfeedback
dc.subjectlight
dc.subjectmelanogaster
dc.subjectoscillations
dc.subjectentrainment
dc.titleA simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM
dc.typeArticle - Refereed
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006349599770785#
dc.date.accessed2014-02-05
dc.title.serialBiophysical Journal
dc.identifier.doihttps://doi.org/10.1016/s0006-3495(99)77078-5


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