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dc.contributor.authorSontag, Eduardo
dc.contributor.authorVeliz-Cuba, Alan
dc.contributor.authorLaubenbacher, Reinhard
dc.contributor.authorJarrah, Abdul Salam
dc.date.accessioned2014-02-26T19:10:05Z
dc.date.available2014-02-26T19:10:05Z
dc.date.issued2008-07
dc.identifier.citationSontag, Eduardo; Veliz-Cuba, Alan; Laubenbacher, Reinhard; Jarrah, Abdul Salaml. "The effect of negative feedback loops on the dynamics of Boolean networks," Biophysical Journal 95(2), 518-526 (2008); doi: 10.1529/biophysj.107.125021
dc.identifier.issn0006-3495
dc.identifier.urihttp://hdl.handle.net/10919/25774
dc.description.abstractFeedback loops play an important role in determining the dynamics of biological networks. To study the role of negative feedback loops, this article introduces the notion of distance-to-positive-feedback which, in essence, captures the number of independent negative feedback loops in the network, a property inherent in the network topology. Through a computational study using Boolean networks, it is shown that distance-to-positive-feedback has a strong influence on network dynamics and correlates very well with the number and length of limit cycles in the phase space of the network. To be precise, it is shown that, as the number of independent negative feedback loops increases, the number (length) of limit cycles tends to decrease (increase). These conclusions are consistent with the fact that certain natural biological networks exhibit generally regular behavior and have fewer negative feedback loops than randomized networks with the same number of nodes and same connectivity.
dc.description.sponsorshipNSF DMS-0614371, DMS-0511441
dc.language.isoen_US
dc.publisherCELL PRESS
dc.subjectdifferential-equations
dc.subjectregulatory networks
dc.subjectbiological networks
dc.subjectkauffman networks
dc.subjectsystems
dc.subjectconvergence
dc.subjectbehavior
dc.subjectcycles
dc.titleThe effect of negative feedback loops on the dynamics of Boolean networks
dc.typeArticle - Refereed
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006349508702297
dc.date.accessed2014-02-05
dc.title.serialBiophysical Journal
dc.identifier.doihttps://doi.org/10.1529/biophysj.107.125021


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