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Modeling-Enabled Characterization of Novel NLRX1 Ligands
(PLOS, 2015-12-29)
Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular sentinels of cytosolic homeostasis that orchestrate immune and inflammatory responses in infectious and immune-mediated diseases. ...
Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection
(PLOS, 2015-07-31)
Clostridium difficile infections are associated with the use of broad-spectrum antibiotics and result in an exuberant inflammatory response, leading to nosocomial diarrhea, colitis and even death. To better understand the ...
Supervised learning methods in modeling of CD4+ T cell heterogeneity
(2015-09-04)
Background
Modeling of the immune system – a highly non-linear and complex system – requires practical and efficient data analytic approaches. The immune system is composed of heterogeneous cell populations and hundreds ...
Obesity and mortality after the first ischemic stroke: Is obesity paradox real?
(2021-02-10)
Background and purpose Obesity is an established risk factor for ischemic stroke but the association of increased body mass index (BMI) with survival after ischemic stroke remains controversial. Many studies have shown ...
A predictive analytics model for differentiating between transient ischemic attacks (TIA) and its mimics
(2020-06-18)
Background
Transient ischemic attack (TIA) is a brief episode of neurological dysfunction resulting from cerebral ischemia not associated with permanent cerebral infarction. TIA is associated with high diagnostic errors ...
Empirical study using network of semantically related associations in bridging the knowledge gap
(2014-11-27)
Background
The data overload has created a new set of challenges in finding meaningful and relevant information with minimal cognitive effort. However designing robust and scalable knowledge discovery systems remains a ...
Clinical Risk Score for Predicting Recurrence Following a Cerebral Ischemic Event
(2019-11-12)
Introduction: Recurrent stroke has a higher rate of death and disability. A number of risk scores have been developed to predict short-term and long-term risk of stroke following an initial episode of stroke or transient ...
Modeling-enabled Systems Nutritional Immunology
(Frontiers, 2016-02-16)
This review highlights the fundamental role of nutrition in the maintenance of health, the immune response, and disease prevention. Emerging global mechanistic insights in the field of nutritional immunology cannot be ...
Trends in ischemic stroke outcomes in a rural population in the United States
(2021-03-15)
Introduction: The stroke mortality rate has gradually declined due to improved interventions and controlled risk factors. We investigated the associated factors and trends in recurrence and all-cause mortality in ischemic ...
SARS-CoV-2 Is a Culprit for Some, but Not All Acute Ischemic Strokes: A Report from the Multinational COVID-19 Stroke Study Group
(2021-03)
Background. SARS-CoV-2 infected patients are suggested to have a higher incidence of thrombotic events such as acute ischemic strokes (AIS). This study aimed at exploring vascular comorbidity patterns among SARS-CoV-2 ...