Now showing items 1-6 of 6
Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel
Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...
Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates
(Springer Nature, 2017-11-17)
Determining the mechanisms by which a species adapts to its environment is a key endeavor in the study of evolution. In particular, relatively little is known about how transcriptional processes are fine-tuned to adjust ...
Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection
Helicobacter pylori colonizes half of the world’s population as the dominant member of the gastric microbiota resulting in a lifelong chronic infection. Host responses toward the bacterium can result in asymptomatic, ...
Insights into the Evolution of Longevity from the Bowhead Whale Genome
(Cell Press, 2015-01-06)
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly ...
Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system
Background Experimental evolution studies, coupled with whole genome resequencing and advances in bioinformatics, have become a powerful tool for exploring how populations respond to selection at the genome-wide level, ...
Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster
Background Evolutionary theory predicts that antagonistically selected alleles, such as those with divergent pleiotropic effects in early and late life, may often reach intermediate population frequencies due to balancing ...