Now showing items 1-10 of 98
e-Connections, vol. 1, no. 2; Summer 2006
(Virginia Bioinformatics Institute, Virginia Tech, 2006-07-06)
TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen
(Public Library of Science, 2009-11-06)
The regulation of intracellular levels of reactive oxygen species (ROS) is critical for developmental differentiation and virulence of many pathogenic fungi. In this report we demonstrate that a novel transmembrane protein, ...
A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus
(Public Library of Science, 2008-11-07)
At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must ...
An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
(Public Library of Science, 2009-01-09)
Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-gamma hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA ...
e-Connections, vol. 4, no. 3; Fall 2009
(Virginia Bioinformatics Institute, Virginia Tech, 2009-09-24)
Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome
The serial analysis of gene expression (SAGE) method is used to study global gene expression in cells or tissues in various experimental conditions. However, its reproducibility has not yet been definitively assessed. In ...
VMD: a community annotation database for oomycetes and microbial genomes
The VBI Microbial Database (VMD) is a database system designed to host a range of microbial genome sequences. At present, the database contains genome sequence and annotation data of two plant pathogens Phytophthora sojae ...
Virginia Bioinformatics Institute 2004 Annual Report
(Virginia Bioinformatics Institute, 2005-01-17)
e-Connections, vol. 2, no. 4; Winter 2007
(Virginia Bioinformatics Institute, Virginia Tech, 2008-01-07)
Pathogens: 2006 Annual Report
(Virginia Bioinformatics Institute, 2007-01-31)