Now showing items 1-10 of 653
The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pesti
(Public Library of Science, 2010-08-09)
Background: Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category ...
Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells
Background Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because of its diverse pharmacological characteristics. Although resveratrol possesses chemopreventive ...
Microbial communities and diazotrophic activity differ in the root-zone of Alamo and Dacotah switchgrass Feedstocks
Nitrogen (N) bioavailability is a primary limiting nutrient for crop and feedstock productivity. Associative nitrogen fixation (ANF) by diazotrophic bacteria in root-zone soil microbial communities have been shown to provide ...
Named Entity Recognition for Bacterial Type IV Secretion Systems
(Public Library of Science, 2011-03-29)
Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen ...
Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
(PLoS ONE, 2011-11-16)
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and ...
Systematic Construction of Kinetic Models from Genome-Scale Metabolic Networks
The quantitative effects of environmental and genetic perturbations on metabolism can be studied in silico using kinetic models. We present a strategy for large-scale model construction based on a logical layering of data ...
e-Connections, vol. 1, no. 2; Summer 2006
(Virginia Bioinformatics Institute, Virginia Tech, 2006-07-06)
The Condition-Dependent Transcriptional Landscape of Burkholderia pseudomallei
(Public Library of Science, 2013-09-12)
Burkholderia pseudomallei (Bp), the causative agent of the often-deadly infectious disease melioidosis, contains one of the largest prokaryotic genomes sequenced to date, at 7.2 Mb with two large circular chromosomes (1 ...
Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer
Dependence on the glutamine pathway is increased in advanced breast cancer cell models and tumors regardless of hormone receptor status or function. While 70% of breast cancers are estrogen receptor positive (ER+) and ...
Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis
Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that were isolated from different hosts, including representatives of the Ovis and Equi biovars. A ...