Now showing items 1-10 of 18
Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress
(Nature Publishing Group, 2017-03-06)
The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic ...
Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation
(Nature Publishing Group, 2016-09-02)
Oscillatory Dynamics of Cell Cycle Proteins in Single Yeast Cells Analyzed by Imaging Cytometry
Progression through the cell division cycle is orchestrated by a complex network of interacting genes and proteins. Some of these proteins are known to fluctuate periodically during the cell cycle, but a systematic study ...
Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif
(Nature Publishing Group, 2017-02-22)
Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains. At these sites, TLRs interact with ...
Plant Invasions Associated with Change in Root-Zone Microbial Community Structure and Diversity
The importance of plant-microbe associations for the invasion of plant species have not been often tested under field conditions. The research sought to determine patterns of change in microbial communities associated with ...
Computational Modeling-Based Discovery of Novel Classes of Anti-Inflammatory Drugs That Target Lanthionine Synthetase C-Like Protein 2
Background: Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine synthetase component C-Like protein family involved in signal transduction and insulin sensitization. Recently, ...
Dietary alpha-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-gamma
Background: Treatments for inflammatory bowel disease (IBD) are modestly effective and associated with side effects from prolonged use. As there is no known cure for IBD, alternative therapeutic options are needed. Peroxisome ...
Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin
(Nature Publishing Group, 2017-10-20)
Genome diversity of tuber-bearing Solanum uncovers complex evolutionary history and targets of domestication in the cultivated potato
(Natl Acad Sciences, 2017-11-14)
Cultivated potatoes (Solanum tuberosum L.), domesticated from wild Solanum species native to the Andes of southern Peru, possess a diverse gene pool representing more than 100 tuber-bearing relatives (Solanum section ...