Search
Now showing items 1-10 of 72
Germline excision of transgenes in Aedes aegypti by homing endonucleases
(Nature Publishing Group, 2013-04)
Aedes (Ae.) aegypti is the primary vector for dengue viruses (serotypes1-4) and chikungunya virus. Homing endonucleases (HEs) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific ...
Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma
(Public Library of Science, 2012-01-05)
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have ...
A Network Biology Approach to Denitrification in Pseudomonas aeruginosa
(2015-02-23)
Pseudomonas aeruginosa is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, P. aeruginosa can perform (complete) denitrification, a respiratory process of ...
A Computational Model of Liver Iron Metabolism
(Public Library of Science, 2013-11-07)
Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular ...
The PLOS ONE Synthetic Biology Collection: Six Years and Counting
(Public Library of Science, 2012-08-15)
Since it was launched in 2006, PLOS ONE has published over fifty articles illustrating the many facets of the emerging field of synthetic biology. This article reviews these publications by organizing them into broad ...
Policy Trap and Optimal Subsidization Policy under Limited Supply of Vaccines
(Public Library of Science, 2013-07-01)
We adopt a susceptible-infected-susceptible (SIS) model on a Barabási and Albert (BA) network to investigate the effects of different vaccine subsidization policies. The goal is to control the prevalence of the disease ...
High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid
(PLOS, 2015-08-13)
Disease modifying treatments for Alzheimer’s disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive ...
A Simulation Optimization Approach to Epidemic Forecasting
(PLOS, 2013-06-27)
Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents ...
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study
(PLOS, 2013-06-18)
Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. We used Illumina® Next Generation Sequencing (NGS) technology to gain unbiased biological ...
Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection
(Public Library of Science, 2010-01-15)
Human lung epithelial cells are likely among the first targets to encounter invading severe acute respiratory syndromeassociated coronavirus (SARS-CoV). Not only can these cells support the growth of SARS-CoV infection, ...