Recent Submissions

  • Folate regulates RNA m5C modification and translation in neural stem cells 

    Xu, Xiguang; Johnson, Zachary; Wang, Amanda; Padget, Rachel L.; Smyth, James W.; Xie, Hehuang (2022-11-23)
    Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to ...
  • Natural and Engineered Sex Ratio Distortion in Insects 

    Compton, Austin; Tu, Zhijian (Frontiers, 2022-06-15)
    Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and ...
  • Mapping the cell-membrane proteome of the SKBR3/HER2+ cell line to the cancer hallmarks 

    Lazar, Iulia M.; Karcini, Arba; Haueis, Joshua R. S. (PLOS, 2022-08-01)
    The hallmarks of biological processes that underlie the development of cancer have been long recognized, yet, existing therapeutic treatments cannot prevent cancer from continuing to be one of the leading causes of death ...
  • The SKBR3 cell-membrane proteome reveals telltales of aberrant cancer cell proliferation and targets for precision medicine applications 

    Karcini, Arba; Lazar, Iulia M. (Nature Portfolio, 2022-06-27)
    The plasma membrane proteome resides at the interface between the extra- and intra-cellular environment and through its various roles in signal transduction, immune recognition, nutrient transport, and cell-cell/cell-matrix ...
  • Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder 

    Raghavan, Ramkripa; Anand, Neha S.; Wang, Guoying; Hong, Xiumei; Pearson, Colleen; Zuckerman, Barry; Xie, Hehuang; Wang, Xiaobin (Springer Nature, 2022-07-09)
    Alterations in tryptophan and serotonin have been implicated in various mental disorders; but studies are limited on child neurodevelopmental disabilities such as autism spectrum disorder (ASD) and attention-deficit ...
  • Editorial: Signaling Proteins for Endosomal and Lysosomal Function 

    Capelluto, Daniel G. S.; Conde, Cecilia B.; Tumbarello, David A.; van den Bogaart, Geert (Frontiers, 2021-12-16)
  • Mutation and selection explain why many eukaryotic centromeric DNA sequences are often A + T rich 

    Barbosa, Anne C.; Xu, Zhengyao; Karari, Kazhal; Williams, Wendi; Hauf, Silke; Brown, William R. A. (Oxford University Press, 2022-01-11)
    We have used chromosome engineering to replace native centromeric DNA with different test sequences at native centromeres in two different strains of the fission yeast Schizosaccharomyces pombe and have discovered that A ...
  • mobileOG-db: a Manually Curated Database of Protein Families Mediating the Life Cycle of Bacterial Mobile Genetic Elements 

    Brown, Connor L.; Mullet, James; Hindi, Fadi; Stoll, James E.; Gupta, Suraj; Choi, Minyoung; Keenum, Ishi M.; Vikesland, Peter J.; Pruden, Amy; Zhang, Liqing (American Society for Microbiology, 2022-08-29)
    Bacterial mobile genetic elements (MGEs) encode functional modules that perform both core and accessory functions for the element, the latter of which are often only transiently associated with the element. The presence ...
  • A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment 

    Cornelison, R. Chase; Yuan, J. X.; Tate, Kinsley M.; Petrosky, A.; Beeghly, G. F.; Bloomfield, Mathew; Schwager, S. C.; Berr, A. L.; Stine, Caleb A.; Cimini, Daniela; Bafakih, F. F.; Mandell, J. W.; Purow, B. W.; Horton, B. J.; Munson, Jennifer M. (Nature Portfolio, 2022-07-29)
    Glioblastoma is an aggressive brain cancer characterized by diffuse infiltration. Infiltrated glioma cells persist in the brain post-resection where they interact with glial cells and experience interstitial fluid flow. ...
  • The PH Domain and C-Terminal polyD Motif of Phafin2 Exhibit a Unique Concurrence in Animals 

    Hasan, Mahmudul; Capelluto, Daniel G. S. (MDPI, 2022-07-07)
    Phafin2, a member of the Phafin family of proteins, contributes to a plethora of cellular activities including autophagy, endosomal cargo transportation, and macropinocytosis. The PH and FYVE domains of Phafin2 play key ...
  • Neuronal Depolarization Induced RNA m5C Methylation Changes in Mouse Cortical Neurons 

    Xu, Xiguang; Johnson, Zachary; Xie, Hehuang (MDPI, 2022-06-29)
    Neuronal activity is accomplished via substantial changes in gene expression, which may be accompanied by post-transcriptional modifications including RNA cytosine-5 methylation (m5C). Despite several reports ...
  • Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase 

    Vijayakumari, Drisya; Mueller, Janina; Hauf, Silke (Cell Press, 2022-03-22)
    Cdc48 (p97/VCP) is a AAA-ATPase that can extract ubiquitinated proteins from their binding partners and can cooperate with the proteasome for their degradation. A fission yeast cdc48 mutant (cdc48-353) shows low levels of ...
  • Aedes aegypti sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology 

    Martin-Martin, Ines; Leon, Paola Carolina Valenzuela; Amo, Laura; Shrivastava, Gaurav; Iniguez, Eva; Aryan, Azadeh; Brooks, Steven; Kojin, Bianca B.; Williams, Adeline E.; Bolland, Silvia; Ackerman, Hans; Adelman, Zach N.; Calvo, Eric (Cell Press, 2022-04-12)
    Saliva from mosquitoes contains vasodilators that antagonize vasoconstrictors produced at the bite site. Sialokinin is a vasodilator present in the saliva of Aedes aegypti. Here, we investigate its function and describe ...
  • Anopheles mosquitoes reveal new principles of 3D genome organization in insects 

    Lukyanchikova, Varvara; Nuriddinov, Miroslav; Belokopytova, Polina; Taskina, Alena; Liang, Jiangtao; Reijnders, Maarten J. M. F.; Ruzzante, Livio; Feron, Romain; Waterhouse, Robert M.; Wu, Yang; Mao, Chunhong; Tu, Zhijian Jake; Sharakhov, Igor V.; Fishman, Veniamin (Nature Portfolio, 2022-04-12)
    Chromosomes are hierarchically folded within cell nuclei into territories, domains and subdomains, but the functional importance and evolutionary dynamics of these hierarchies are poorly defined. Here, we comprehensively ...
  • LYSMD3: A mammalian pattern recognition receptor for chitin 

    He, Xin; Howard, Brad A.; Liu, Yang; Neumann, Aaron K.; Li, Liwu; Menon, Nidhi; Roach, Tiffany; Kale, Shiv D.; Samuels, David C.; Li, Hongyan; Kite, Trenton; Kita, Hirohito; Hu, Tony Y.; Luo, Mengyao; Jones, Caroline N.; Okaa, Uju Joy; Squillace, Diane L.; Klein, Bruce S.; Lawrence, Christopher B. (2021-07-20)
    Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense ...
  • Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines 

    Ahuja, Shreya; Lazar, Iulia M. (2021-09-09)
    Background Microglia safeguard the CNS against injuries and pathogens, and in the presence of certain harmful stimuli are capable of inducing a disease-dependent inflammatory response. When exposed to anti-inflammatory ...
  • Mutations that alter Arabidopsis flavonoid metabolism affect the circadian clock 

    Hildreth, Sherry B.; Littleton, Evan S.; Clark, Leor C.; Puller, Gabrielle C.; Kojima, Shihoko; Winkel, Brenda S. J. (Society for Experimental Biology, 2022-02-26)
    Flavonoids are a well-known class of specialized metabolites that play key roles in plant development, reproduction, and survival. Flavonoids are also of considerable interest from the perspective of human health, as both ...
  • Species-Specificity in Thermopreference and CO2-Gated Heat-Seeking in Culex Mosquitoes 

    Reinhold, Joanna M.; Chandrasegaran, Karthikeyan; Oker, Helen; Crespo, José E.; Vinauger, Clément; Lahondère, Chloé (MDPI, 2022-01-14)
    Combining thermopreference (Tp) and CO2-gated heat-seeking assays, we studied the thermal preferendum and response to thermal cues in three Culex mosquito species exhibiting ...
  • Recent Progress in Lyme Disease and Remaining Challenges 

    Bobe, Jason R.; Jutras, Brandon L.; Horn, Elizabeth J.; Embers, Monica E.; Bailey, Allison; Moritz, Robert L.; Zhang, Ying; Soloski, Mark J.; Ostfeld, Richard S.; Marconi, Richard T.; Aucott, John; Ma'ayan, Avi; Keesing, Felicia; Lewis, Kim; Ben Mamoun, Choukri; Rebman, Alison W.; McClune, Mecaila E.; Breitschwerdt, Edward B.; Reddy, Panga Jaipal; Maggi, Ricardo; Yang, Frank; Nemser, Bennett; Ozcan, Aydogan; Garner, Omai; Di Carlo, Dino; Ballard, Zachary; Joung, Hyou-Arm; Garcia-Romeu, Albert; Griffiths, Roland R.; Baumgarth, Nicole; Fallon, Brian A. (Frontiers, 2021-08-18)
    Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has ...
  • The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar 

    DeHart, Tanner G.; Kushelman, Mara R.; Hildreth, Sherry B.; Helm, Richard F.; Jutras, Brandon L. (Springer Nature, 2021-11-24)
    Peptidoglycan—a mesh sac of glycans that are linked by peptides—is the main component of bacterial cell walls. Peptidoglycan provides structural strength, protects cells from osmotic pressure and contributes to shape. All ...

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