Recent Submissions

  • Fatgraph models of RNA structure 

    Huang, Fenix; Reidys, Christian; Rezazadegan, Reza (De Gruyter, 2017-02-08)
    In this review paper we discuss fatgraphs as a conceptual framework for RNA structures. We discuss various notions of coarse-grained RNA structures and relate them to fatgraphs. We motivate and discuss the main intuition ...
  • Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel 

    Kang, Lin; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Mahaney, James E.; Rzigalinski, Beverly A.; Korol, Abraham; Nevo, Eviatar; Michalak, Pawel (2019-06-11)
    Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...
  • Diminished single-stimulus response in vmPFC to favorite people in children diagnosed with Autism Spectrum Disorder 

    Kishida, Kenneth T.; De Asis-Cruz, Josepheen; Treadwell-Deering, Diane; Liebenow, Brittany; Beauchamp, Michael S.; Montague, P. Read (2019-07)
    From an early age, individuals with autism spectrum disorder (ASD) spend less time engaged in social interaction compared to typically developing peers (TD). One reason behind this behavior may be that the brains of children ...
  • Insights into the Evolution of Longevity from the Bowhead Whale Genome 

    Keane, Michael; Semeiks, Jeremy; Webb, Andrew E.; Li, Yang I.; Quesada, Victor; Craig, Thomas; Madsen, Lone Bruhn; van Dam, Sipko; Brawand, David; Marques, Patricia I.; Michalak, Pawel; Kang, Lin; Bhak, Jong; Yim, Hyung-Soon; Grishin, Nick V.; Nielsen, Nynne Hjort; Heide-Jorgensen, Mads Peter; Oziolor, Elias M.; Matson, Cole W.; Church, George M.; Stuart, Gary W.; Patton, John C.; George, J. Craig; Suydam, Robert; Larsen, Knud; Lopez-Otin, Carlos; O'Connell, Mary J.; Bickham, John W.; Thomsen, Bo; de Magalhaes, Joao Pedro (Cell Press, 2015-01-06)
    The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly ...
  • Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism 

    Fachi, Jose Luis; Felipe, Jaqueline de Souza; Pral, Lais Passariello; da Silva, Bruna Karadi; Correa, Renan Oliveira; Pereira de Andrade, Mirella Cristiny; da Fonseca, Denise Morais; Basso, Paulo Jose; Saraiva Camara, Niels Olsen; de Sales e Souza, Ericka Lorenna; Martins, Flaviano dos Santos; Sato Guima, Suzana Eiko; Thomas, Andrew Maltez; Setubal, Joao Carlos; Magalhaes, Yuli Thamires; Forti, Fabio Luis; Candreva, Thamiris; Rodrigues, Hosana Gomes; de Jesus, Marcelo Bispo; Consonni, Silvio Roberto; Farias, Alessandro dos Santos; Varga-Weisz, Patrick; Ramirez Vinolo, Marco Aurelio (Cell Press, 2019-04-16)
    Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features ...
  • Same influenza vaccination strategies but different outcomes across US cities? 

    Taylor, Claudia; Marathe, Achla; Beckman, Richard (International Society for Infectious Diseases, 2010-09)
    Objectives: This research aimed to determine if the same influenza vaccination strategies would have the same level of effectiveness when applied to two different US metropolitan areas, Miami and Seattle, where the composition ...
  • Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays 

    Scaria, Joy; Chen, Jenn-Wei; Useh, Nicodemus; He, Hongxuan; McDonough, Sean P.; Mao, Chunhong; Sobral, Bruno; Chang, Yung-Fu (International Society for Infectious Diseases, 2014-10)
    Objectives: Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number ...
  • Dual African Origins of Global Aedes aegypti s.l. Populations Revealed by Mitochondrial DNA 

    Moore, Michelle; Sylla, Massamba; Goss, Laura; Burugu, Marion Warigia; Sang, Rosemary; Kamau, Luna W.; Kenya, Eucharia Unoma; Bosio, Chris; de Lourdes Munoz, Maria; Sharakhova, Maria V.; Black, William Cormack (PLOS, 2013-04)
    Background: Aedes aegypti is the primary global vector to humans of yellow fever and dengue flaviviruses. Over the past 50 years, many population genetic studies have documented large genetic differences among global ...
  • Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq 

    Anderson, Leticia; Amaral, Murilo S.; Beckedorff, Felipe; Silva, Lucas F.; Dazzani, Bianca; Oliveira, Katia C.; Almeida, Giulliana T.; Gomes, Monete R.; Pires, David S.; Setubal, Joao C.; DeMarco, Ricardo; Verjovski-Almeida, Sergio (PLOS, 2015-12)
    Background Schistosomiasis is one of the most prevalent parasitic diseases worldwide and is a public health problem. Schistosoma mansoni is the most widespread species responsible for schistosomiasis in the Americas, Middle ...
  • Reproductive Incompatibility Involving Senegalese Aedes aegypti (L) Is Associated with Chromosome Rearrangements 

    Dickson, Laura B.; Sharakhova, Maria V.; Timoshevskiy, Vladimir A.; Fleming, Karen L.; Caspary, Alex; Sylla, Massamba; Black, William C. (PLOS, 2016-04)
    Aedes aegypti, the primary vector of dengue, yellow fever and Zika flaviviruses, consists of at least two subspecies. Aedes aegypti (Aaa) is light in color, has pale scales on the first abdominal tergite, oviposits in ...
  • Cooler Temperatures Destabilize RNA Interference and Increase Susceptibility of Disease Vector Mosquitoes to Viral Infection 

    Adelman, Zach N.; Anderson, Michelle A. E.; Wiley, Michael R.; Murreddu, Marta G.; Samuel, Glady Hazitha; Morazzani, Elaine M.; Myles, Kevin M. (PLOS, 2013-05)
    Background: The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic ...
  • Optimization of sand fly embryo microinjection for gene editing by CRISPR/Cas9 

    Martin-Martin, Ines; Aryan, Azadeh; Meneses, Claudio; Adelman, Zach N.; Calvo, Eric (PLOS, 2018-09)
    Background Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology ...
  • Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making 

    Boribon, Brittany P.; Lenzi, Mark J.; Li, Liwu; Jones, Caroline N. (Frontiers, 2019-03-12)
    Neutrophils are the first responders to infection and play a pivotal role in many inflammatory diseases, including sepsis. Recent studies have shown that lipopolysaccharide (LPS), a classical pattern recognition molecule, ...
  • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

    Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (Springer Nature, 2019-06-12)
    The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
  • Advancing livestock genomics education and research in developing countries using strategies from the Virginia Tech PREP and IMSD training programs 

    Smith, Edward (2019-07-11)
    Our unique and impactful research and education program plan includes distinct activities that target three overlapping phases of each trainee’s tenure, which we define as the “moving in,” “moving through,” and “moving ...
  • ICESat-2 Early Adopter Summary Results 

    Abbott, A.; Wynne, Randolph H.; Thomas, Valerie A. (2019-05-02)
  • Structure and Function of Ecosystems Mission 

    Wynne, Randolph H.; Ranson, Jon; Thomas, Valerie A.; Campbell, Petya; Cavender-Bares, Jeannine; Dabney, Philip; Gamon, John; Huemmrich, Fred; Harding, David; McCorkel, Joel; Middleton, Elizabeth; Parker, Geoffrey; Torres, Victor; Townsend, Philip (2019-06-13)
  • Site Index, LAI, and Previous Thinning 

    Wynne, Randolph H.; Thomas, Valerie A. (2019-05-31)
    Forest Productivity Cooperative Webinar
  • Growth, Removals, and Management Intensity 

    Wynne, Randolph H.; Thomas, Valerie A.; Bender, Stacie; Brooks, Evan; Coulston, John; Derwin, Jill; Gopalakrishnan, Ranjith; Green, Patrick; Harding, David; Sumnall, Matthew; Joshi, Pratik; Ranson, Jon; Schleeweis, Karen; Thomas, Robert; Yang, Zhiqiang (2019-05-01)

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