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dc.contributor.authorStaniar, William Burtonen_US
dc.date.accessioned2014-03-14T20:07:41Z
dc.date.available2014-03-14T20:07:41Z
dc.date.issued2002-01-25en_US
dc.identifier.otheretd-02222002-135203en_US
dc.identifier.urihttp://hdl.handle.net/10919/26273
dc.description.abstractThis group of experiments focused on relationships between diet, somatotropic axis, and growth. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are factors in the somatotropic axis, and important to development of growth cartilage in the young animal. The entire study was divided into four main experiments. Characteristics of growth in 113 Thoroughbred foals born over a five year period were described with a series of empirical and physiological equations. Glycemic and insulinemic responses to different feed compositions were evaluated with glycemic response tests. The 24 hr pattern of plasma glucose, insulin, GH, and IGF-I was described in yearlings fed two meals a day. Finally, an association between ADG and IGF-I was described in Thoroughbreds from birth to 16 mo of age. Feeding diets to the foal that influence the somatotropic axis during growth may affect development of growth cartilage in unexpected or detrimental ways. The pattern of weight in Thoroughbred foals from birth to 16 mo of age was most closely described by multiple regression with a combination of age, girth, body length, and physeal circumference (R2 = 0.99). Glycemic and insulinemic responses were significantly higher in yearlings fed a sugar and starch supplement when compared to those fed a fat and fiber supplement (P = 0.043 and 0.031; respectively). Glucose and insulin secretion was significantly affected by the feeding of two meals in a 24 hr period (P < 0.0001). Plasma IGF-I was positively correlated with ADG from birth to 16 mo of age in foals fed either a fat and fiber or sugar and starch supplement (r = 0.34, P < 0.0001). The results from the series of experiments described here suggest a possible role of dietary mangement in reducing the risk of skeletal disorders that involve the influence of IGF-I on chondrocyte maturation.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartwbsphd1.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectThoroughbred foalsen_US
dc.subjectglycemic responseen_US
dc.subjectgrowthen_US
dc.subjectsomatotropic axisen_US
dc.titleGrowth and the Somatotropic Axis in Young Thoroughbredsen_US
dc.typeDissertationen_US
dc.contributor.departmentAnimal and Poultry Sciencesen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
dc.contributor.committeechairKronfeld, David S.en_US
dc.contributor.committeememberHerbein, Joseph H. Jr.en_US
dc.contributor.committeememberHoward, Rick Daleen_US
dc.contributor.committeememberAkers, Robert Michaelen_US
dc.contributor.committeememberLawrence, Larry A.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-02222002-135203/en_US
dc.date.sdate2002-02-22en_US
dc.date.rdate2003-02-22
dc.date.adate2002-02-22en_US


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