Synthesis and Characterization of Novel Polyethers and Polydimethylsiloxanes for Use in Biomaterials
|dc.description.abstract||This dissertation focuses on the use of novel polyethers and polydimethylsiloxanes in the stabilization of magnetite nanoparticles as well as biomedical applications. The colloidal stabilities of magnetite nanoparticles coated with polyethers containing various functional endgroups were studied. Different variables (e.g. polymer loading, polyether molecular weight and type of functional anchor group) were investigated to determine their effect on the long-term physiological stability of the polyether magnetite complexes.
One-part PDMS-magnetite nanoparticle fluids were synthesized using a high shear process and magnetic separation techniques. These one-part fluids are unique in the fact that they do not require the addition of a non-functional PDMS oligomer solvent to generate a magnetic hydrophobic fluid. A series of PDMS-magnetite nanoparticle fluids containing different molecular weight stabilizers were synthesized. A magnetic separation study was performed to determine if PDMS molecular weight influences the magnetic separation profiles of the fluids.
Well-defined PDMS-b-PtBA and PDMS-b-poly(acrylic acid) copolymers were synthesized using living free radical techniques from novel PDMS precursors as well as PDMS-based ionenes with different hard segment groups.
|dc.rights||I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.||en_US|
|dc.title||Synthesis and Characterization of Novel Polyethers and Polydimethylsiloxanes for Use in Biomaterials||en_US|
|dc.contributor.department||Macromolecular Science and Engineering||en_US|
|thesis.degree.grantor||Virginia Polytechnic Institute and State University||en_US|
|thesis.degree.discipline||Macromolecular Science and Engineering||en_US|
|dc.contributor.committeechair||Riffle, Judy S.||en_US|
|dc.contributor.committeemember||Dailey, J. P.||en_US|
|dc.contributor.committeemember||Davis, Richey M.||en_US|
|dc.contributor.committeemember||McGrath, James E.||en_US|
|dc.contributor.committeemember||Esker, Alan R.||en_US|
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