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Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol Virginia Polytechnic Institute and State University; Kingston, David G.; Molinero, Anthony A.; Gunatilaka, A. Leslie (United States Patent and Trademark Office, 1995-11-28)The natural product cephalomannine can be converted to the important anticancer natural product taxol by a simple process involving the steps of dihydroxylation to give cephalomannine-diols, diol cleavage, benzoylation at ...
Liu, Changhui (Virginia Tech, 2004-05-10)Taxol (1) was first isolated from the bark of the Pacific yew about 35 years ago by Drs. Wall and Wani. Although its development as an anticancer agent was delayed by numerous reasons, including its scarcity and insolubility, ...