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dc.contributor.authorWilliams, Russell B.en_US
dc.date.accessioned2014-03-14T20:19:35Z
dc.date.available2014-03-14T20:19:35Z
dc.date.issued2005-11-29en_US
dc.identifier.otheretd-12012005-181123en_US
dc.identifier.urihttp://hdl.handle.net/10919/29861
dc.description.abstractThrough the ICBG (International Cooperative Biodiversity Group) program and a continuing search for anticancer compounds, plant extracts were obtianed from Suriname and Madagascar and screened for cytotoxic activity in the A2780 human ovarian cancer cell line. Fractionation of a leaf and flower extract of Casearia nigrescens led to the isolation of six new clerodane diterpenes. Four were new natural products and the other two were previously unreported hydrolysis products. Their structures were determined using mass spectrometry and 1-D and 2-D NMR. All six compounds were cytotoxic in the A2780 human ovarian cancer cell line. Fractionation of a leaf extract of Vernonia pachyclada led to the isolation of four new sesquiterpene lactones. Their structures were determined using mass spectrometry, 1-D and 2-D NMR, and (in one case) single crystal X-ray diffraction. All four compounds were cytotoxic in the A2780 human ovarian cancer cell line. Fractionation of an extract of Casimirella ampla led to the isolation of three new diterpenes and two known diterpenes. Their structures were determined using mass spectrometry and 1-D and 2-D NMR. All five compounds were cytotoxic in the A2780 human ovarian cancer cell line. Fractionation of root and stem extracts of Mendoncia cowanii led to the isolation of two new naphthaquinones, and two known naphthaquinones. Their structures were determined using mass spectrometry and 1-D and 2-D NMR. All four compounds were cytotoxic in the A2780 human ovarian cancer cell line and three compounds exhibited weak inhibition of Akt kinase. The fractionation of five additional extracts resulted in the isolation of twelve known compounds. Their structures were determined using mass spectrometry, 1-D and 2-D NMR, and comparison to literature data. All twelve compounds were cytotoxic in the A2780 human ovarian cancer cell line.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartDissertation.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectCytotoxicen_US
dc.subjectAnticanceren_US
dc.subjectNatural Productsen_US
dc.subjectDiterpeneen_US
dc.subjectNaphthaquinoneen_US
dc.subjectCasimerella amplaen_US
dc.subjectMendoncia cowaniien_US
dc.subjectVernonia pachycladaen_US
dc.subjectCasearia nigrescensen_US
dc.subjectSesquiterpene lactoneen_US
dc.titleSearching for Anticancer Natural Products From the Rainforest Plants of Suriname and Madagascaren_US
dc.typeDissertationen_US
dc.contributor.departmentChemistryen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberCarlier, Paul R.en_US
dc.contributor.committeememberGandour, Richard D.en_US
dc.contributor.committeememberTanko, James M.en_US
dc.contributor.committeememberTaylor, Larry T.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12012005-181123/en_US
dc.date.sdate2005-12-01en_US
dc.date.rdate2005-12-09
dc.date.adate2005-12-09en_US


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